Za tři desetiletí se technika in vitro oplození proměnila z oboru, v který věřil jen málokdo, na techniku, která je pevnou součástí moderní medicíny. Obavy, které s ní byly spojovány, se nenaplnily. Naopak, in vitro oplození našlo uplatnění i tam, kde to nikdo nepředpokládal. V kombinaci s předimplantační genetickou diagnostikou se využívá jako prevence dědičných onemocnění. Potřeba oplození in vitro se ukázala i v zemích třetího světa, které se potýkají s důsledky populační exploze. V současnosti se rozvíjejí nové biotechnologie, které narážejí na odpor veřejnosti. Historie se opakuje. Jsou zdůrazňovány především jejich možná i ryze hypotetická rizika a mnohé jejich budoucí přínosy nejsou a za současného stavu poznání ani nemohou být předvídány. Rozvoj in vitro oplození nabízí lekci pro hodnocení nastupujících biotechnologií. Jejich výrazné omezení nebo dokonce zákaz by zjevně znamenaly pro budoucnost lidstva závažná omezení., During the past three decades, human in vitro fertilization (IVF) has changed from disdained technique to one which constitutes a respected branch of modern medicine. Concerns connected with human in vitro fertilization have not materialized. On the other hand, in vitro fertilization has demonstrated benefits in unexpected areas. When combined with techniques of molecular genetics such as preimplantation genetic diagnostics, it can prevent the occurrence of hereditary diseases. In vitro fertilization is greatly needed even in developing countries, despite the fact that the Third World is heavily confronted with the impacts of population explosion. At present, many new and promising biotechnologies are fighting strong opposition from the public. The history of human IVF recurs. Even hypothetical risks are emphasized, and many future benefits are not recognized or cannot be recognized at the present state of knowledge. The significant progress of human IVF provides us with a lesson for the evaluation of impending biotechnologies. The setting of rigid limits or imposing bans on new biotechnologies can significantly restrict the future prosperity of mankind., and Radko Rajmon, Miroslava Krejčová, Jaroslav Petr
Hymenální atrézie - potažmo její důsledky - je vzácnou příčinou bolestí v podbřišku u dospívajících dívek, snadno zaměnitelnou za chirurgickou etiologii obtíží. Gynekologické vyšetření dívek a žen před chirurgickou intervencí je nezbytnou součástí diagnostického algoritmu, v případě atrézie hymen tímto lze v některých případech předejít abdominálnímu operačnímu řešení obtíží. Tato kazuistika demonstruje překvapivý nález v dutině břišní u 15leté dívky s bolestmi břicha, primárně chirurgem operované pro diagnózu „akutní apendicitida“. Kromě klinického obrazu jsme v tomto případě byli svědky i poměrně nezvyklého nálezu laboratorního - extrémně vysoké hodnoty CA 125., Hymenal atresia – and its results in fact - is the rare cause of pelvic or abdominal pain in pubescent girls, which could be changed for surgical cause of ailment easily. Gynecologic examination should be a part of a diagnostic algorithm in women and young girls before every surgical intervention - we can avoid an abdominal operation in case of hymenal atresia. This case report demonstrates a surprising finding in 15 years old girl, which was primarily operated by surgeon for diagnosis „acute appendicitis“. In this particular case next to clinical findings there was an extremely high value of CA 125 marker in laboratory., Lukáš Straka, and Literatura
The aim of the study was to establish the frequency of hypovitaminosis D in children with type 1 diabetes mellitus (T1D), its influence on biochemical and densitometric parameters and the relation to diabetic nephropathy. 58 children with T1D at the age 9–19 years were enrolled to the study. Vitamin D concentration less than 30 ng/ml was considered as insufficient. 37 children (63.79%) had vitamin D level under 30 ng/ml, from these 19 subjects (32.7%) had vitamin D level under 20 ng/ml and 2 subjects (3.44%) under 10 ng/ml. Children with vitamin D deficiency had significantly lower magnesium concentration and lower Z score of lumbar spine (−1.34 ± 1.24 vs. −0.30 ± 1.21, p = 0.01) compared to diabetics with sufficient vitamin D concentration. No significant difference was found in parameters calcium, phosphorus or glycosylated hemoglobin. Patients with diabetic nephropathy (n = 18) showed no significant difference in vitamin D, glycosylated hemoglobin or Z score of lumbar spine compared to the patients without nephropathy (n = 40). Subjects with nephropathy had significantly longer diabetes duration, significantly higher cholesterol and triacylglycerol concentration. In our cohort of patients nearly two thirds of children had insufficient vitamin D concentration what supports the need to monitor and eventually supplement vitamin D in T1D subjects., Jarmila Vojtková, Miriam Čiljaková, Lenka Vojarová, Katarína Janíková, Zuzana Michnová, Veronika Šagiová, and Literatura 35
Prezentujeme kazuistiku pacientky s iatrogenní lézí levého močovodu, u které byla diagnóza stanovena po měsíci od gynekologické operace. Hlavními příznaky, kterých si pacientka všimla, byly zvětšující se objem břicha a difuzní bolesti v bříšní oblasti. I přes provedené CT-IVU diagnóza nebyla stanovena. Až senzitivnější ascendentní ureteropyelografie prokázala lézi močovodu. Při nejasnostech je vždy vhodné provedení nejcitlivější diagnostické metody, We present a case report of a patient with an iatrogenic lesion of the left ureter diagnosed one month after gynecological surgery. The main symptoms were abdominal distension and abdominal pain. A CT-IVP was not diagnostic. Only a subsequent reterograde urogram was more sensitive and demonstrated a ureteric lesion. It is always advisable to perform the most sensitive diagnostic methods when in doubt., Jakub Szewczyk, Jan Krhut, Henryk Fikoczek, Ivana Kalusková, and Literatura
Viral hepatitis B and C is a relevant issue because of high prevalence and degree of chronicity, late diagnosis and poor prognosis. Today, protein products of numerous genes are involved in the pathogenesis of viral pathology of the liver. In this review, the authors analysed 42 literature sources on genetic basis of susceptibility to various infectious diseases. Study of the role of immunogenetic factors is of great practical importance to develop methods for predicting outcomes of viral hepatitis., Khamid Karimov, Sevara Azimova, Bakhtiyor Iriskulov, and Literatura
We report the case of a 52year old man with severe acute pancreatitis. In this case report we discuss the undesirable effects of parenteral nutrition and the importance of nutritional support at patients with severe necrotizing pancreatitis. Severe acute pancreatitis is usually accompanied by systemic inflammatory response syndrome, which results in hypermetabolism with prominent protein catabolism. Providing nutrition to these patients is of paramount importance. An adequate nutritional support is crucial in patients with severe and complicated pancreatitis. A negative energy balance has a negative impact on the nutritional status and the disease progression., Shpata Vjollca, Kuneshka Loreta, Kurti Floreta, Ohri Ilir, and Literatura
Birth rate regulation is a major problem of modern medicine. Unfortunately, frequency of artificial abortions is still high not only in developing, but also in developed countries. Abortion results in severe gynecologic and endocrine complications in the woman’s body (Alieva, 2001). Use of intrauterine devices (IUDs) is a most effective method of contraception. A great number of studies in the field of utilization and possible complications of IUDs revealed the occurrence of inflammatory diseases of small pelvis organs (IDSPO). Andizhan (Uzbekistan). Duration of patients’ follow-up ranged 40 days to 6 months. Women did not have contraindications for IUDs according to WHO medical eligibility criteria. Blood was a material for study; it was taken in 40 days, 3 and 6 months following IUD insertion. After insertion of copper IUDs to women, a cytokine cascade was studied in dynamics. in this test system made 4 pg/ml. During the study, the women of the test group showed increased proinflammatory cytokines. The further study of vaginal smears confirmed development of bacterial vaginoses in them that suggests a relation of complications due to IUDs with imbalance of the cytokine cascade. Elevated serum concentration of cytokines was revealed in women with IUDs already on the first days of their application. European Medical, Health and Pharmaceutical Journal ISSN 1804-5804 Sharp increase in IL-1 on days 40 and 90 after insertion of IUDs is associated with presence of complications in the form of expulsions and possible development of inflammatory diseases of small pelvis organs., Umida Yusupova, Farida Ayupova, and Literatura
To study efficiency of the combined treatment of advanced gastric cancer with inclusion Trastuzumab. Material: We present the intermediate analysis of the use of target therapy with Trastuzumab in patients with a HER2positive gastric cancer. Up to 01.10.2009y 118 patients have been tested for HER2 expression, and in 24 gastric cancer patients it is revealed HER2positive status of tumor. It is lead chemotherapy to all patients by the PLF regimen and Herceptin in doze 6 mg/kg once in 3 weeks (6 cycles). In control group in 26 patients it is lead only chemotherapy by the PLF regimen once in 3 weeks without addition Trastuzumab (6 cycles). Results: At the moment of the analysis of preliminary data, the median remission duration in compared groups has made 8.3 months, and 5.2 months, accordingly. Conclusion: At advanced gastric cancer with high level HER2 expression Trastuzumab increases frequency of objective effect and the median remission duration., M. D. Juraev, D. M. Egamberdiev, S. S. Khudayorov, H. N. Tuyev, and Literatura