Plants of pepper (Capsicum amuum L.) were grown in controlled environment chambers at ambient (360 pmol mol"*) and fluctuating pulse-enriched CO2 concentrations (700 pmol mol"* daily average, ranging from 500 to 3500 pmol mol"* = ECO2) under two water regimes. A decrease in plant growth and yield together with frequent visual injuries was found in plants growing under ECO2. Root/shoot ratio was greater, chlorophyll concentration and respiration rates were lower, and stomatal conductance and relative importance of alternativě pathway respiration were higher under ECO2. The negative effects of ECO2 were more intense under high water availability. The symptoms produced by ECO2 were similar to those of resource limitation, and were alleviated with increased nutrient supply. Constant elevated CO2 concentrations (700 pmol mol"*) increased pepper production and did not produce any of the injuries described for this erratic ECO2 treatment. Thus, it is probably the erratic nátuře of the CO2 concentration and not the gas itself that was causing the injiuy.
Many physiological and pathological processes in the cardiac tissue have been shown to be associated with a release of endothelin (ET) peptides and with induction of specific ET-receptors and G-protein-coupled ion channels. However, the exact mechanism regulating ET-receptors in the myocardium is controversial. The response to ET-1, the most important member of the ET family, is rapidly attenuated by down-regulation of ET-receptors. The internalization of ET-1 bound to two subclasses of specific receptors (ETA and ETB) that are abundant in the myocardium has been hypothesized to activate and/or inhibit a variety of intracellular signal transducing systems. The [125I]ET-1, BQ-3020 and selective ET-antagonists were used to study the subtype-selective component of regulation of ET-1 receptors in myocardial membranes. We determined the characteristics of [125I]ET-1 binding and [3H]thymidine incorporation in whole cell saturation studies and measured Ca 2+ channel induction and the total number of inactive Ca2+ channels in photoaffinity studies with [3H]azidopine. Here we demonstrate four important components of the complex ET-1 response in human, porcine and rat myocardium, leading to aberrant responses of cells. After ET-1 induction, adaptive subtype-ETB selective down-regulation predominated in human embryonic fibroblasts, in porcine membrane vesicles and in microsomal membranes of renal hypertensive rats, with preferential high affinity ET-1 binding to ETA receptors and with the resultant ETA mediated proliferative and mitogenic activation of human fibroblasts. The ET-1 induction was also accompanied by profound inactivation of Ca2+ channels in myocardial membranes., J. Dřímal, M. Mislovičová, A. Ismail, F. Monček., and Obsahuje bibliografii
Frequent deaths of children deeply influenced the general death rate in the past. The curve of natimortality nearly created the curve of general mortality, because very many new-boms died during the first year of life. This was affected by the standard of breastfeeding in a given society, so the rate of natimortality, as well as the general infant mortality was markedly different locally. The infant mortality in two adjoining towns of Frýdek and Místek kept above 500%o until the mid-19th century and it droped below this limit as late as the second half of the 19th century, though slightly (439%o in Frýdek, 457%o in Mistek). The difference between the situation in both towns manifested itself in the categories of foetal mortality and perinatal mortality. In Frýdek, the perinatal mortality was lower, but the foetal mortality was higher than in Mistek. That is why these categories were examined in this article in greater detail with regard to the complicated classification of the „time of death“ of newly-born children, as well as the leakage of foetal mortality data, and with regard to the problems of spontaneous abortions or infanticide. Causes of deaths were taken into account too, nevertheless only within the classification of diseases used at that time, it means especially the rate of various accidents, incl. abortions, the extent of influence that infectious diseases and avitaminosis exerted on the death rate.
František Pražák ; [s původní litografií Maxe Švabinského a v úpravě Cyrila Boudy], 550 čísl. výt. na ručním maršovském papíře, Bubla 6801, and Bibliofilie