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1251. Deset let s otevřenou vědou

Creator:
Jirásková, Petra
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, Akademie věd České republiky, popularizace vědy, programy a projekty, vzdělávání, popularization of science, programs and projects, education, 12, and 00
Language:
Czech
Description:
Petra Jirásková.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

1254. Despite similar reduction of blood pressure and renal ANG II and ET-1 levels aliskiren but not losartan normalizes albuminuria in hypertensive Ren-2 rats

Creator:
Zdeňka Vaňourková, Herbert J. Kramer, Zuzana Husková, Luděk Červenka, and Ivana Vaněčková
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, hypertenze, hypertension, Ren-2 rats, renin-angiotensin system, endothelin system, RAS blockade, aliskiren, losartan, albuminuria, 14, and 612
Language:
English
Description:
The relationship between angiotensin II (ANG II) and endothelin-1 (ET-1) is known to be complex; both peptides can initiate and potentiate the gene expression of each other. This pilot study investigated the effects of the AT1 receptor blocker losartan or the direct renin inhibitor aliskiren on mean arterial pressure (MAP) and albuminuria and the renal ANG II and ET-1 levels. 3-month-old male Ren-2 transgenic rats (TGR) were treated either with losartan (5 mg kg-1 day-1) or aliskiren (10 mg kg-1 day-1) for 10 weeks. At the end of the experiment, rats were decapitated and cortical and papillary parts of kidneys were separated. Plasma and tissue ANG II levels were measured by RIA and tissue ET-1 concentrations by ELISA. In all four groups of animals ET-1 levels were lowest in renal cortex and more than 100-fold higher in the papilla. Cortical and papillary ET-1 concentrations in untreated TGR significantly exceeded those of control HanSD rats and were significantly depressed by both drugs. In both strains, papillary ANG II concentrations were moderately but significantly higher than cortical ANG II, TGR exhibited higher ANG II levels both in cortex and papilla as compared to control HanSD rats. Aliskiren and losartan at the doses used depressed similarly the levels of ANG II in cortex and papilla and reduced ET-1 significantly in the renal cortex and papilla below control levels in HanSD rats. Albuminuria, which was more than twice as high in TGR as in HanSD rats, was normalized with aliskiren and reduced by 28 % with losartan, although MAP was reduced to a similar degree by both drugs. Despite similar reductions of MAP and renal ET-1 and ANG II levels aliskiren appears to be more effective than losartan, at the doses used, in reducing albuminuria in heterozygous hypertensive Ren-2 rats., Z. Vaňourková ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

1255. Destruction of marginal parts of sandstone plateaus in the protected landscape area Bohemian Paradise

Creator:
Forczek, Ingrid
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Geologie. Meteorologie. Klimatologie, sesuvy půdy, landslides, block movements, hazard, cleft cave, 7, and 551
Language:
English
Description:
The article deals with geodynamical phenomena of marginal parts of sandstone plateaus. The area of interest consists of several partial areas in the Bohemian Paradise natural reserve. These areas rise above terrain as relics of a once uniform sandstone plateau. The current relief developed mainly in the Pleistocene, when the Jizera River carved present day wide valley and the underlying soft clay rocks were uncovered. Thus favorable conditions were created for slow destruction of sandstone plateaus. Here, the slope movements occur up to the present days in the form of landsliding and slow block movements and their epiphenomena. Due to this continuing activity of the slope movements, human settlements and cultural monuments are endangered. Research in this area helps us to clarify the relation between slope movements and other factors, such as the presence of a significant tectonic failure in the vicinity or the influence of the water regime., Ingrid Forczek., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

1256. Detailed brittle tectonic analysis of the limestones in the quarries near Vápenná village (case study)

Creator:
Nováková, Lucie
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Geologie. Meteorologie. Klimatologie, vápenec, lomy, limestones, quarries, Vápenná (Česko), Vápenná (Czechia), brittle tectonics, paleostress analysis, Branná group, 7, and 551
Language:
English
Description:
This paper describes limestone body situated in the northern part of the Branná group near Vápenná village in Javorník area. The body is confined by two major tectonic zones of this area - Sudetic Marginal Fault on the east and Ramzová overthrust on the south. Detailed tectonic analysis has been performed in two big limestone quarries named quarry I and II. Strikes and dips of fault planes and joints were measured. In the quarry I just one important orientation of the fault planes was found - WE mostly vertical. In the quarry II two main fault plane orientations were observed - vertical NW-SE Sudetic and NE-SW Moravo-Silesian. The senses of movements in the fault planes were determined using the calcite steps mainly as the kinematic indicators. Presence of the kinematic indicators allowed performing of paleostress analysis. Several different tectonic phases were identified and discussed., Lucie Nováková., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

1257. Detection and possible role of proteasomes in the bronchoalveolar space of the injured lung

Creator:
Majetschak, M., Sorell, L. T., Patricelli, T., Seitz, D. H., and Knöferl, M. W.
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, 26S proteasome, 20S core particle, 19S regulator complex, ubiquitin, ubiquitin-protein ligase, 14, and 612
Language:
English
Description:
Recent observations suggest the presence of 20S proteasomes (20S) in the lung epithelial lining fluid. However, the physiological relevance of 20S in the alveolar space and possible contribution to disease processes are unknown. Thus, we evaluated whether extracellular proteasomes could have a pathophysiological role in the injured lung using a rat model of lung contusion (LC). Bronchoalveolar lavage fluids (BALF) were obtained at various time points for up to 168 h after LC or sham procedure. Enzyme activities, ELISA and Western blots indicated enzymatically active 20S, the 19S subunit Rpt5 and ubiquitin in BALF. 20S and ubiquitin increased significantl y after LC, peaked at 24 h and normalized within 168 h. Mg 2+ /ATP-dependent peptidase activities were detectable 6-24 h after LC. BALF after LC also contained ubiquitin-protein-ligase activity. Addition of Mg 2+ /ATP to BALF after LC led to significant proteolysis and could be prevented with epoxomicin and EDTA. These data suggest for the first time that the Mg 2+ /ATP-dependent 26S proteasome complex exists outside the cell, is released into the lung epithelial lining fluid after LC and contribute s to the proteolysis of the bulk of protein in the alveolar space of the injured lung. We infer that proteasome complexes may have a pathophysiological role during lung edema clearance., M. Majetschak, L. T. Sorell, T. Patricelli, D. H. Seitz, M. W. Knöferl., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

1258. Detection of Antiendothelial Cell Antibodies in Patients with Connective Tissue Diseases by Flow Cytometry and Their Relation to Endothelial Cell Activation

Creator:
Marcela Horváthová, Eva Jahnová, and Štefan Nyulassy
Format:
print, bez média, and svazek
Type:
article, studie, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Antiendothelial cell antibodies, Adhesion molecules, Expression, Flow cytometry, 14, and 612
Language:
English
Description:
Antiendothelial cell antibodies (AECA) have been detected by flow cytometry analysis in 23 out of 80 patients with connective tissue diseases. Ten out of 19 serum samples from patients with systemic lupus erythematosus (SLE) were positive. These antibodies were not detectable in healthy donors. We examined the capacity of serum samples to induce endothelial cell activation by modulating cell adhesion molecule expression on human umbilical vein endothelial cells. We found that sera from both AECA-positive and AECA-negative patient groups induced a significantly higher expression of E-selectin compared to healthy controls (P<0.05). There were no differences in the ICAM-1 on VCAM-1 expression. Our data suggest that increased E-selectin expression in activated endothelium in patients with various connective tissue disorders is not related to the production of AECA., M. Horváthová, E. Jahnová, Š. Nyulassy., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

1259. Detection of cervical lymph node micrometastases in patients with squamous cell carcinoma of the oral cavity, pharynx and larynx

Creator:
Čelakovský, Petr, Kalfeřt, David, Smatanová, Katarína, Chrobok, Viktor, and Laco, Josef
Format:
print, text, and regular print
Type:
model:article, article, Text, časopisecké články, práce podpořená grantem, and TEXT
Subject:
spinocelulární karcinom--patologie--chirurgie, ženské pohlaví, lidé, nádory hrtanu--patologie--chirurgie, lymfadenektomie--metody, mužské pohlaví, lidé středního věku, nádory úst--patologie--chirurgie, disekce krku--metody, mikrometastázy--diagnóza--patologie, staging nádorů, péče o pacienty - plánování, nádory hltanu--patologie--chirurgie, prediktivní hodnota testů, prognóza, prospektivní studie, and reprodukovatelnost výsledků
Language:
English
Description:
BACKGROUND: The goal of this prospective study was to determine the frequency of micrometastases in patients with squamous cell carcinoma (SCC) of the oral cavity, pharynx and larynx in whom elective neck dissection was indicated (cN0). PATIENTS AND METHODS: A total of 12 patients (10 males and 2 females) were enrolled in the study. The age ranged 42-73 years (median 62 years). Elective neck dissection was performed in all patients (8 ipsilateral, 4 bilateral) and a total of 256 lymph nodes were removed and sent for microscopic examination. RESULTS: The presence of tumor cells in cervical lymph nodes was found in 5/12 (42%) patients. Micrometastases of SCC were found in two patients and isolated tumor cells (ITC) in two other patients. In the remaining one patient with oropharyngeal SCC, a micrometastasis of papillary thyroid carcinoma (PTC) was detected. Positive lymph nodes were localized in level II in three patients with SCC of larynx, hypopharynx and tongue base, respectively, in level I in one patient with SCC of oral tongue and in level III in one patient with PTC. CONCLUSION: Our results indicate that SCC of head and neck has a high potential for creating micrometastases which frequency is higher compared to clinically detected macrometastases. Therefore, elective neck dissection or radiotherapy of the neck should be considered in patients with high risk of occult metastases or micrometastases. and P. Čelakovský, D. Kalfeřt, K. Smatanová, V. Chrobok, J. Laco
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

1260. Detection of earth impact craters aided by the detailed global gravitational model EGM2008

Creator:
Jaroslav Klokočník, Jan Kostelecký, Pavel Novák, and Carl A. Wagner
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Geologie. Meteorologie. Klimatologie, gravitační odchylky, gravity anomalies, global gravitational model, second-order derivative of the disturbing potential, impact craters on the Earth, 7, and 551
Language:
English
Description:
We have surveyed the Earth's surface using gravity anomalies and second-order radial derivatives of the disturbing gravitational potential computed from the gravitational model EGM2008 complete to degree and order 2159 (for selected degrees up to 2190). It corresponds to 5 arcmin resolution on the ground. Over most well known impact crater sites on the Earth we found the second-order derivatives (not available from ordinary gravity surveys) offered finer discrimination of circular features than the gravity anomalies themselves. We also discovered that some of the sites show evidence of double or multiple craters which will need further ground verification. Some of these signatures (in hilly or mountainous terrain) may also need to be corrected for the gravitational effect of topography to sharpen their hidden features., Jaroslav Klokočník, Jan Kostelecký, Pavel Novák and Carl A. Wagner., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

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