In addition to providing subsistence and consumable resources, one of the most important features of water is the ability to provide transport and communication between geographically separated areas. In both uses, vehicles play a key role. While current research into boats and ships on the seas is relatively well recognised, recent results in the area of inland waterways seem to be barely taken into account in current investigations. Too foten scientist have to rely on an otdate state of research, but in fact several findings have laterl been re-edited and presented. This article provides an updated look at the subject of inland navigation in the Early and Hig Middle Ages and focuses especially on current pbuliactions or those that are difficult to obtain. Further, an overview on the state of research in neighbouring countries is offered, thereby presenting a fuller view of the subject´s potentional., Lars Kröger., and Obsahuje seznam literatury
Tato studie se zabývá dvěma spřízněnými jevy odehrávajícími se ve vědeckém prostředí. Jedná se o fenomén frustrace ve vědecké praxi a s ním spojenou touhu po rozpoznání vlastního výzkumu vědeckou komunitou a ná- sledně o otázku uznání od akademického společenství. Zmíněné fenomény jsou přitom úzce propojeny s ústředním tématem fi losofi e a sociologie vědy: kdo rozhoduje, co bude předmětem vědeckého bádání? Předkládaná studie nejprve představuje Mertonův mýtus o okamžitém rozpoznání vědeckého objevu a následně prostřednictvím exkurzu do oblasti ekonomie a na příkladech z vědecké praxe (zejména na životech Karla Poppera a Michaela Faradaye) poukazuje na jeho neplatnost. V závěru textu jsou společně s jejich dekonstrukcí navrhnuta možná řešení popsaných problémů. Text je také kritickým návratem ke dvěma studiím Josepha Agassiho, žáka Karla R. Poppera a tvrdošíjného zastánce kritického racionalismu, neboť právě Agassi ve svých dílech rozebírá dopady vědeckého vyloučení a neochoty naslouchat., This study deals with two related phenomena that take place in scientific environment. The first one under review is the frustration in scientific practice which is closely associated with the desire for recognition of our own research by the scientific community. Both of these phenomena are strongly tied to the problematic aspect of recognition given by the academic community. The aforementioned occurrences are yet closely linked with the central theme of philosophy and sociology of science: who decides what will be subjected to the scientific inquiry? The article deals with Merton’s myth of immediate recognition in scientific discovery and for its deep analysis uses the excursion into economic field. Text further points out on malfunction of the described Mertonian myth in contemporary science by the use of examples from scientific practice (mainly from the lives of Karl Popper and Michael Faraday). Final argument proposes solutions to described problems together with their deconstruction. The text also represents a critical review of two studies by Joseph Agassi, a stubborn supporter of critical rationalism. Because it was Agassi, a loyal disciple of Karl Popper, who discussed in detail the implications of scientific exclusion and unwillingness to listen., and Ondřej Sloup.
The FTO gene variants are the most important genetic determinants of body weight and obesity known so far, but the mechanism of their effect remain s unclear. We have analyzed FTO rs17817449 variant (G>T in first intron) in 6024 adults aged 45-69 years to assess the potential mediating role of diet and physical activity. Diet was assessed by a 140-item food frequency questionnaire. Physical activity was measured by hours spent during a typical week by sport, walking and other activities outside of work requiring heavy and medium physical activity. Basal metabolic rate was calculated according Schofield formula. The FTO variant was significantly associated with body mass index (means in GG, GT and TT ca rriers were 28.7, 28.2 and 27.8 kg/m 2 , p<0.001) and basal metabolic rate (BMR) (means in GG, GT and TT were 1603, 1588 and 1576 kcal per day, respectively, p<0.008) but it was not associated with physical activity, total energy intake or with energy intakes from fat, carbohydrates, proteins or alcohol. Results were essentially similar in men and women and the adjustment for physical activity or dietary energy intake did not reduce the effect of the FTO polymorphism. Means of BMR per kg of body weight was lowest in GG carriers (20.09, 20.21 for GT and 20.30 for TT, p< 0.006) and this effect was more pronounced in females. These results suggest that the effect of the FTO rs17817449 variant on BMI in Caucasian adults is not mediated by energy intake or physical activity, but some effect on BMR per kg of body weight is possible., J. A. Hubáček ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy