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5352. ECG body surface mapping (BSM) in type 1 diabetic patients
- Creator:
- Denisa Žďárská, Pavlína Pelíšková, Jiří Charvát, Jaroslav Slavíček, Mikuláš Mlček, Eva Medová, and Otomar Kittnar
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, diabetes mellitus, elektrokardiogramy, human physiology, electrocardiograms, diabetes mellitus 1. typu, vektorkardiogram (VCG), mapování potenciálu z povrchu těla, diabetes mellitus type 1, vectorcardiogram (VCG), body surface potential maps (BSPM), 14, and 612
- Language:
- English
- Description:
- a1_Diabetes mellitus is a risk factor of cardiovascular diseases. ECG of patients with diabetes mellitus type 1 (DM 1) shows tachycardia (block of parasympathetic innervation) and abnormal repolarization (increased QT interval and QT dispersion (QTd)) indicating a risk of ventricular tachycardia and sudden death in young people with DM 1. The aim of the present report was to measure 145 parameters of the heart electric field in 22 patients (14 men, 8 women) with DM 1 without complications (mean age 32.8±11.4 years) and in 22 controls (11 men, 11 women, mean age 30.1±3.4 years). The duration of diabetes was 13.9 ±7.8 years. The parameters were regist ered by the diagnostic system Cardiag 112.2 and statistically evaluated by the Student and Mann-Whitney test. Tachycardia (86.3±2.7 beats.min-1), shortening of both QRS (79.9±1.6 ms) and QT (349.0±5.9 ms) and increased QT dispersion (115±36 ms) were observed in DM 1 when compared with the controls (75.0±2.1 beats. min -1, QRS 89.9±2.7 ms, QT 374.0±4.4 ms, QTd 34.0±12.0 ms, p<0.01). The QTc was 415.2±4.1 ms in DM 1 and 401.4±6.6 ms in controls (NS)., a2_Other significant findings in DM 1 were: higher maximum of depolarization isopotential maps (DIPMmax) in the initial phase of QRS and less positive in the terminal phase, more negative minimum (DIPMmin) during QRS similarly as the minimum in depolarization isointegral maps (DIIMmin) and the minimum in isointegral map of the Q wave (Q-IIMmin), lower maximum in repolarization isopotential maps (RIPMmax) and less negative minimum (RIPMmin), more negative amplitude of Q wave (Q-IPMAM) and more pronounced spread of depolarization (activation time). Our results confirmed a decreased parasympathetic to sympathetic tone ratio (tachycardia, shortening of the activation time) and revealed different depolarization and repolarization patterns in DM 1. The differences in heart electric field parameters measured by the BSPM method in DM 1 and in the controls indicate the importance of ECG examination of diabetic patients type 1 in the prevention of cardiovascular diseases., D. Žďárská, P. Pelíšková, J. Charvát, J. Slavíček, M. Mlček, E. Medová, O. Kittnar., and Obsahuje bibiografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
5353. ECG body surface mapping changes in type 1 diabetic patients with and without autonomic neuropathy
- Creator:
- Sabina Pálová, Szabo, K., Jiří Charvát, Jaroslav Slavíček, Eva Medová, Mikuláš Mlček, and Otomar Kittnar
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, diabetes mellitus, diabetes mellitus type 1, autonomic neuropathy, ECG body surface mapping, 14, and 612
- Language:
- English
- Description:
- ECG body surface mapping (BSM) parameters in patients with diabetes mellitus Type 1 (DM1) are significantly different comparing to healthy non-diabetic subjects. Hypothesis that these changes are more pronounced in DM1 patients with autonomic neuropathy (AN) was tested. The parameters of BSM were registered by diagnostic system Cardiag 112.2 in 54 DM1 patients including 25 with AN and 30 control subjects. AN was diagnosed according to Ewing criteria when two or more Ewing tests were abnormal. In classic 12-lead ECG the heart rate was increased, QRS and QT shortened (p<0.01) and QTC prolonged in DM1 patients. The VCG measurement of QRS-STT angles and spatial QRS-STT angle showed non-significant differences. The absolute values of maximum and minimum in depolarization and repolarization isopotential, isointegral, isoarea maps were significantly different in DM1 patients in comparison with controls (p<0.01). The changes were more pronounced in DM1 patients with AN than in DM patients without AN (p<0.05). The QT duration measured in 82 leads of thorax was significantly shortened in 68 leads of both groups of DM 1 patients (p<0.01) when compared with controls. In 34 of them this shortening was more pronounced in DM1 patients with AN than in DM1 patients without AN (p<0.05). The results showed that the method of ECG BSM is capable to confirm the presence of autonomic neuropathy in diabetic patients., S. Palová ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
5354. ECG body surface mapping in patients with gestational diabetes mellitus and optimal metabolic compensation
- Creator:
- Eva Žákovičová, Otomar Kittnar, Jaroslav Slavíček, Eva Medová, Přemysl Šváb, and Jiří Charvát
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, echokardiografie, srdeční rytmus, diabetes mellitus, echocardiography, heart rate, ECG body surface mapping, heart rate variability, gestational diabetes mellitus, 14, and 612
- Language:
- English
- Description:
- Women with gestational diabetes mellitus (GDM) are at increased risk for cardiovascular diseases (CVD) events compared with women without GDM. The aim of the present study was to evaluate 200 parameters of the heart electric field in 35 women with GDM under optimal glycemic compensation compared to 32 healthy pregnant women. All examinations were performed in the 36th week of gestation. The parameters in ECG body surface mapping (BSM) were registered by the diagnostic system Cardiag 112.2. The absolute values of maximum and minimum in depolarization and repolarization isopotential, isointegral and isoarea maps were not significantly different between the groups. These findings correspond to the result of heart rate variability examination. However BSM revealed the significant prolongation of QRS complex (p=0.05), shortening of ventricular myocardial activation time (ICHVAT) (p=0.01), prolongation of mean QT duration (p=0.01) and increase of QT interval dispersion (p=0.01) in women with GDM. Duration of QRS and ICHVAT significantly correlated with interventricular septum and posterior wall thickness in GDM group, QTd interval correlated significantly with HbA1C level. We conclude that despite of optimal metabolic control several significant abnormalities detected by ECG BSM are still present in patients with GDM., E. Žákovičová, O. Kittnar, J. Slavíček, E. Medová, P. Šváb, J. Charvát., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
5355. Echinobothrium megacanthum sp. n. (Cestoda: Diphyllidea) from the eagle ray Myliobatis goodei (Chondrichthyes: Rajoidei) from the Patagonian shelf of Argentina
- Creator:
- Ivanov, Veronica A. and Campbell, Ronald A.
- Format:
- Type:
- model:internalpart and TEXT
- Subject:
- Diphyllidea, Echinobothrium, taxonomy, Myliobatis goodei, and Argentina
- Language:
- English
- Description:
- A new species of Echinobothrium is described from the spiral intestine of the eagle ray Myliobatis goodei Garman
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
5356. Echinoccoccus multilocularis (Cestoda: Taeniidae) in the Czech republic: the first detection of metacestodes in a naturally infected rodent
- Creator:
- Martínek, Karel, Kolářová, Libuše, Červený, Jaroslav, and Andreas, Michal
- Format:
- Type:
- model:internalpart and TEXT
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
5357. Echinococcus multilocularis vesicular fluid inhibits activation and proliferation of natural killer cells
- Creator:
- Bellanger, Anne-Pauline, Mougey, Valentine, Pallandre, Jean-René, Gbaguidi-Haore, Houssein, Godet, Yann, and Millon, Laurence
- Format:
- print, počítač, and online zdroj
- Type:
- model:article and TEXT
- Subject:
- imunitní reakce, immune response, NK cells, alveolar echinococcosis, CD69, 2, and 59
- Language:
- English
- Description:
- Alveolar echinococcosis is a severe chronic helminthic disease that mimics slow-growing liver cancer. The immune evasion strategy of Echinococcus multilocularis Leuckart, 1863 remains poorly understood. The aim of this study was to investigate in vitro the impact of E. multilocularis vesicular fluid (Em-VF) on peripheral blood mononuclear cells (PBMC) and on natural killer (NK) cells. PBMC and NK cells were exposed to Em-VF (1 µg/ml) during six days. The effect of Em-VF was assessed on CD69, viability and proliferation, and on and transforming growth factor β (TGF-β), interferon γ (IFN-γ), interleukin 17 (IL-17) and interleukin 10, using flow cytometry and ELISA, respectively. Exposure to Em-VF had no bearing on PBMC's viability, proliferation and expression of CD69. In contrast, higher levels of IL-17 at day three and of TGF-β at day six were observed in PBMC supernatant after exposure to Em-VF (p < 0.05, Wilcoxon signed-rank test). Exposure to Em-VF induced a significant decrease of CD69 expression of NK cells at day three and a significant decrease of proliferation of NK cells at day six (p < 0.05, Wilcoxon signed-rank test). In contrast, NK cells viability and levels of cytokines did not vary significantly over Em-VF stimulation. Exposure to Em-VF had a significant bearing on activation and proliferation of NK cells. NK cells may play an important role in the immune response of the host against E. multilocularis., Anne-Pauline Bellanger, Valentine Mougey, Jean-René Pallandre, Houssein Gbaguidi-Haore, Yann Godet, Laurence Millon., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
5358. Echinokokové infekce – vzácná postižení jater – editorial - komentář
- Creator:
- Stejskal, František
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, komentáře, úvodníky, and TEXT
- Language:
- Czech
- Description:
- František Stejskal
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
5359. Echokardiografické hodnotenie funkcie myokardu u pacientov s reumatoidnou artritídou bez klinických prejavov kardiovaskulárneho postihnutia
- Creator:
- Beňačka, O., Beňačka, J., Blažíček, Pavol, Belanský, M., Vojtek, V., Ondrejkovič, M., Payer, Juraj, Killinger, Zdenko, and Lietava, Ján
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, abstrakt z konference, and TEXT
- Language:
- Czech and Slovak
- Description:
- O. Beňačka, J. Beňačka, P. Blažíček, M. Belanský, V. Vojtek, M. Ondrejkovič, J. Payer, Z. Killinger, J. Lietava
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
5360. Echolokace a hlasové projevy rejskovitých hmyzožravců. I. Orientace v prostoru a seismické vibrace
- Creator:
- Schneiderová, Irena
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Biologické vědy, rejskovití, Soricidae, Česko, Czechia, orientace v prostoru, orientace v prostředí, echolokace, bělozubky, akustické monitorování, vnitrodruhová komunikace, dorozumívání zvířat, seismické vibrace, echolocation, Crocidurinae, 2, and 57/59
- Language:
- Czech
- Description:
- Rejskovití hmyzožravci (čeleď Soricidae) jsou drobní savci, kterých si v přírodě často sotva všimneme. Vyznačují se však mnoha zajímavostmi, díky kterým rozhodně stojí za naši pozornost. K těmto zajímavostem lze zařadit i schopnost echolokace, tj. schopnost orientovat se v prostoru za pomoci ozvěn cvakání, které vydávají. Kromě cvakání se během pohybu prostředím patrně orientují i pomocí štěbetavých hlasů. Bělozubky hnědé (Suncus murinus) při pohybu v neznámém prostředí také „duní“. Zda se i toto dunění uplatňuje při orientaci v prostoru není zatím jasné. Bělozubky pouštní (Diplomesodon pulchellum) zase při přechodu mezi různými typy substrátu vibrují, a tyto vibrace vytvářené celým tělem jim pravděpodobně pomáhají odhadnout vlastnosti substrátu a vyhnout se tak zbytečnému hrabání v hustém písku., Shrews (Soricidae) are small mammals that can be barely noticed in nature. However, there are many interesting facts that make them noteworthy, including echolocation - the ability to navigate with the help of echoes of the clicks they produce. Apart from the clicks, twitters are also probably used for navigation. The Asian House Shrew (Suncus murinus) moving through an unfamiliar environment produces boom, but it is not yet clear whether this sound is used for navigation. The Piebald Shrew (Diplomesodon pulchellum) produces body vibrations in response to a change in the substrate under their feet. These vibrations may be used for exploration of substrate density to avoid digging in dense sand., and Irena Schneiderová.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public