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7174. GIP-dependent expression of hypothalamic genes

Creator:
Ambati, S., Duan, J., Hartzell, D. L., Choi, Y.-H., Della-Fera, M. A., and Baile, C. A.
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, GIP receptor knockout, ICV administration, mRNA expression, rats, mice, 14, and 612
Language:
English
Description:
GIP (glucose dependent insulinotr ophic polypeptide), originally identified as an incretin peptide synthesized in the gut, has recently been identified, along with its receptors (GIPR), in the brain. Our objective was to investigate the role of GIP in hypothalamic gene expression of biomarkers linked to regulating energy balance and feeding behavi or related neurocircuitry. Rats with lateral cerebroventricular cannulas were administered 10 μg GIP or 10 μl artificial cerebrospinal fluid (aCSF) daily for 4 days, after which whole hypothalami were collected. Real time Taqman™ RT-PCR was used to quantitatively compare the mRNA expression levels of a set of genes in the hypothalamus. Administration of GIP resulted in up-regulation of hypothalamic mRNA levels of AVP (46.9±4.5 %), CART (25.9±2.7 %), CREB1 (38.5±4.5 %), GABRD (67.1±11 %), JAK2 (22.1±3.6 %), MAPK1 (33.8±7.8 %), NPY (25.3±5.3 %), OXT (49.1±5.1 %), STAT3 (21.6±3.8 %), and TH (33.9±8.5 %). In a second experiment the same set of genes was evaluated in GIPR -/- and GIPR +/? mice to determine the effect of lack of GIP stimulation on gene expression. In GIPR -/- mice expressions of the following genes were down-regulated: AVP (27. 1±7.5 %), CART (28.3±3.7 %), OXT (25.2±5.8 %), PTGES (23.9±4.5 %), and STAT3 (8.8±2.3 %). These results suggest that AVP, CART, OXT and STAT3 may be involved in energy balance-related hypothalamic circuits affected by GIP., S. Ambati ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

7175. Girdling interruption between source and sink in Quercus pubescens does not trigger leaf senescence

Creator:
Holland, V., Fragner, L., Jungcurt, T., Weckwerth, W., and Brüggemann, W.
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
metabolomika, metabolomics, fluorescence chlorofylu, změny klimatu, JIP-test, PEA, SPAD, chlorophyll fluorescence, climate change, 2, and 581
Language:
Multiple languages
Description:
Metabolite changes and senescence behaviour after mechanical phloem girdling were studied in leaf tissue of Quercus pubescens. Sugar accumulation is not only considered to be an important part of several developmental signalling pathways, but is also seen as one of the basic triggers for senescence induction, or at least an obligatory accessory phenomenon. Our survey showed that an accumulation of the soluble sugars, glucose and fructose, was not on its own obligatorily connected with the induction of leaf senescence, since no indication or even an onset of senescence could be observed during the course of the experiment. Instead, we observed an inhibition of leaf development with a decrease of photosynthesis and a slow-down of development in nearly all chlorophyll a fluorescence analysis parameters using the JIP-test. We detected a change of metabolites linked to oxidative stress, possibly due to an overexcitation of the developmentally inhibited photosynthetic apparatus., V. Holland, L. Fragner, T. Jungcurt, W. Weckwerth, W. Brüggemann., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

7176. Girdling-induced Alhagi sparsifolia senescence and chlorophyll fluorescence changes

Creator:
Tang, G.-L., Li, X.-Y., Lin, L.-S., Zeng, F.-J., and Gu, Z.-Y.
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
fotosyntéza, photosynthesis, carbon, nutrient cycling, photosynthetic apparatus, photosynthetic pigment, reactive oxygen, stress, 2, and 581
Language:
Multiple languages
Description:
Senescence constitutes the final stage of a plant organ and tissue development and is a subject to gene control and strict regulation. By the late growing season, when Alhagi sparsifolia entered the natural senescence period, a girdling treatment was carried out on the phloem to increase the sugar content in leaves and to investigate carbohydrate-induced leaf senescence. After the semi-girdling and full-girdling treatment, organic matter could not leave leaves due to the destruction of sieve tubes. This led to constantly increasing sugar contents in leaves. Girdling was shown to greatly accelerate the senescence of plants. In girdled leaves, chlorophyll (Chl) a, Chl b, carotenoids (Car), and both ratios of Chl a/b and Chl/Car were significantly reduced. On the donor side of PSII, the oxygen-evolving complex was inhibited under high concentrations of carbohydrates, which was manifested as the emergence of the K phase in fluorescence kinetic curves. On the acceptor side of PSII, the high carbohydrate content also led to the disruption of electron transport and reduced light-use efficiency, which was manifested as a reduction in numerous fluorescence parameters. We believe that the emergence and development of plant senescence was not necessarily induced by the high content of carbohydrates, because even a decrease in the carbohydrate concentration could not stop the senescence process. Although the high content of carbohydrates in plants could induce plant senescence, this kind of senescence was likely a pathological process, including degradations of physiological functions., G.-L. Tang, X.-Y. Li, L.-S. Lin, F.-J. Zeng, Z.-Y. Gu., and Obsahuje seznam literatury
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

7177. GIS a jeho využití v botanice

Creator:
Dana Michalcová
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Botanika, informační systémy, botanika, 2, and 58
Language:
Czech
Description:
Apart from a brief overview of GIS analyses used in botany and an explanation of the differences between two basic data models (vector or grid), the current paper also offers three case studies which used GIS to plan sampling design, explain causes of species composition and model phenological map. and Dana Michalcová, Ondřej Hájek.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

7178. Giulio Cesare in Egitto am Wiener Kärntnertortheater im Jahre 1731: Ein Beitag zur Rezeption der Werke von G. F. Händel in der Habsburgermonarchie in der 1. Hälfte des 18. Jahrhunderts

Creator:
Jana Perutková
Format:
print, bez média, and svazek
Type:
article, studie, studies, model:article, and TEXT
Subject:
Händel, Georg Friedrich, 1685-1759, 1701-1750, dějiny hudby, dějiny opery, hudební skladatelé, muzikologie, recepce hudby, composers, history of music, musicology, reception of music, Vídeň (Rakousko), Vienna (Austria), 78.01, 78.071.1, 78(091), 782(091), 78.073, and (048.8)
Language:
Czech
Description:
Studie Jany Perutkové se zabývá provedením opery "Giulio Cesare in Egitto" od hudebního skladatele Georga Friedricha Händela v divadle U Korutanské brány v císařském hlavním městě Vídni a též širší recepci Händelovy hudby v habsburském soustátí v uvedeném časovém období., The goal of the study is to present certain Händel sources that are unknown or have not yet been researched and to investigate the connection of those sources with the capital city of the Habsburg Monarchy, Vienna. At the center of attention is a performance of a pasticcio of Giulio Cesare in Egitto at the Theater am Kärntnertor in Vienna (Kärntnertortheater) in 1731. The study introduces the printed libretto, which has heretofore been regarded as lost, as well as the score of the work that L. Bennett first brought to light. The rediscovery of the libretto has made possible the comparison of these two sources. Also brought to attention is a copy of a collection of arias from this pasticcio that is held in Bratislava. There is furthermore presentation of certain possibilities regarding the identity of the probable compiler of the pasticcio, the composer Francesco Rinaldi, whose three extant operas premiered in Vienna date from the years 1730–1732. Reference is made in the study to the increased interest in Händel’s works in Vienna around the year 1730, and in connection therewith, reference is also made to a Viennese copy of his opera Admeto, which is kept in Meiningen. The study also asserts that at least one of the scores of Händel’s Agrippina held in the Musiksammlung der Österreichischen Nationalbibliothek had been the property of Count Johann Adam von Questenberg., Jana Perutková., Rubrika: Studie, and České resumé na s. 121, anglický abstarkt na s. 95.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

7180. Giuseppe Verdi

Creator:
Verdi, Giuseppe, Stefan, Paul, and Werfel, Franz
Publisher:
Paul Zsolnay Verlag
Format:
print and 391 stran ; 22 cm
Type:
text, volume, model:monograph, and TEXT
Subject:
Verdi, Giuseppe, 1813-1901, skladatelé, text, korespondence, italská hudba, italská opera, operní skladatelé, italští skladatelé, and biografie
Language:
German
Description:
herausgegeben und eingeleitet von Franz Werfel ; übersetzt vo Paul Stefan and Obsahuje rejstřík
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

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