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8131. Hypoglycemia factitia – atypická hypoglykémia – kazuistika

Creator:
Mokáň, Michal, Nehaj, F., Stančík, Matej, Michalová, R., Samoš, Matej, Galajda, Peter, and Mokáň, Marián
Format:
print, text, and regular print
Type:
model:article, article, Text, abstrakt z konference, and TEXT
Language:
Czech and Slovak
Description:
Michal Mokáň, F. Nehaj, M. Stančík, R. Michalová, M. Samoš, P. Galajda, Marián Mokáň
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

8132. Hypoglykemická terapie u diabetu typu II. část 1

Format:
print, text, and regular print
Type:
model:article, article, Text, and TEXT
Subject:
lidé, diabetes mellitus 2. typu--farmakoterapie--komplikace--mortalita, metformin--terapeutické užití, hemoglobin A glykosylovaný--účinky léků, krevní glukosa--účinky léků, hypoglykemika--terapeutické užití, komplikace diabetu--mortalita--prevence a kontrola, medicína založená na důkazech, randomizované kontrolované studie jako téma, and kardiovaskulární nemoci--mortalita--prevence a kontrola
Language:
Czech
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

8133. Hypoglykemická terapie u diabetu typu II. část 2

Format:
print, text, and regular print
Type:
model:article, article, Text, and TEXT
Subject:
lidé, diabetes mellitus 2. typu--farmakoterapie, metformin--terapeutické užití, komplikace diabetu--prevence a kontrola, hypoglykemika--škodlivé účinky--terapeutické užití, kardiovaskulární nemoci--prevence a kontrola, randomizované kontrolované studie jako téma, hemoglobin A glykosylovaný--účinky léků, lékové interakce, hypoglykemie--chemicky indukované, sulfonylmočovinové sloučeniny--škodlivé účinky, inzulin--škodlivé účinky, inhibitory glykosidových hydroláz--škodlivé účinky, thiazolidindiony--škodlivé účinky, inhibitory dipeptidylpeptidázy 4--škodlivé účinky, peptid 1 podobný glukagonu--škodlivé účinky, transportní proteiny pro sodík a glukosu--antagonisté a inhibitory--škodlivé účinky, kombinovaná farmakoterapie, glifloziny, repaglinid, studie Ukpds, and studie UDGP
Language:
Czech
Description:
Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

8134. Hypoglykemie jako limitace léčby diabetes mellitus

Creator:
Olšovský, Jindřich
Format:
print, text, and regular print
Type:
model:article, article, Text, and TEXT
Subject:
lidé, diabetes mellitus--farmakoterapie, komplikace diabetu, hypoglykemika--škodlivé účinky, hypoglykemie--epidemiologie--chemicky indukované--komplikace--psychologie, inzulin--škodlivé účinky, dlouhodobě působící inzulin--terapeutické užití, rizikové faktory, strach, and kardiovaskulární nemoci--etiologie--komplikace
Language:
Czech and English
Description:
Autor se v článku zabývá problematikou hypoglykemie jako nejčastější komplikace terapie diabetes mellitus (DM). Ukazuje na nebezpečí, kterými hypoglykemie pacienty ohrožují, ale všímá si také rizikových skupin pacientů z hlediska rizika hypoglykemie a také různé míry rizika, která s sebou nesou různá antidiabetika. Klíčová slova: antidiabetika – diabetes mellitus – hypoglykemie, In his paper, the author deals with hypoglycemia-related problems as the most frequent complication of the therapy for diabetes mellitus (DM). He points to threats that patients with hypoglycemia are exposed to, but also gives attention to risk groups of patients with regard to hypoglycemia development as well as different levels of the risk related to different antidiabetics. Key words: antidiabetics – diabetes mellitus – hypoglycemia, and Jindřich Olšovský
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

8136. Hypotéza vymazávání stop a její platnost v češtině u pacientů s Brocovou afázií

Creator:
Hudousková, Andrea, Flanderková, Eva, Mertins, Barbara, and Tomšů, Kristýna
Format:
print, bez média, and svazek
Type:
model:article and TEXT
Subject:
lingvistika, minimalismus (literatura), čeština, syntax, linguistics, minimalist theory (linguistic), Czech language, Brocova afázie, hypotéza vymazávání stop, Broca’s aphasia, Trace Deletion Hypothesis, 11, and 81
Language:
Czech
Description:
This paper presents and discusses the results of an experiment testing the validity of the Trace Deletion Hypothesis (Grodzinsky 1989, 2000) in Czech. The Trace Deletion Hypothesis (= TDH) was proposed to account for a receptive syntactic deficit in Broca’s aphasics that involves structures containing transformational operations such as the passive. According to the assumptions of the TDH, in passive constructions Broca’s aphasics fail to assign a semantic θ-role to the derived subject syntactically, so they assign it the Agent θ-role by linear consideration (Default Principle), which results in a structure with two potential Agents. This strategy is supposed to lead to the chance performance of Broca’s aphasics in these structures, as they are forced to guess the distribution of the Agent and the Patient θ-roles. The results of our experiment, however, do not support the TDH-proposal: out of the six tested subjects, only one performed at chance. The error rate for reversible passive structures in Czech was 33.34%, which corresponds to an above-chance performance. Given these results, the validity of the TDH is called into question, also with respect to the development of the generative theory itself., In diesem Artikel werden Ergebnisse eines Experiments präsentiert und diskutiert, in dem die Validität der sogenannten Spurentilgungshypothese (Trace Deletion Hypothesis – Grodzinsky, 1989, 2000) für das Tschechische überprüft wurde. Die Spurentilgungshypothese (= STH) wurde vorgeschlagen, um rezeptive syntaktische Defizite von Strukturen mit Transformationsoperationen (z. B. das Passiv) zu erklären, die bei Patienten mit Broca-Aphasie auftauchen. Beim Verständnis von Passivkonstruktionen misslingt den Broca-Aphasikern laut der STH die Zuordnung der semantischen θ-Rolle zum syntaktisch derivierten Subjekt. Stattdessen stützen sich die Broca-Aphasiker bei der Zuweisung der Agens θ-Rolle auf die lineare Abfolge der Satzglieder (Default Prinzip), was dazu führt, dass die Struktur aus Sicht der Aphasiker zwei potentielle Agens hat. Diese Strategie führt zu einer zufälligen Wahl, da Broca-Aphasiker die Verteilung zwischen den Agens und Patiens θ-Rollen raten müssen. Die Ergebnisse des hier vorgestellten Experiments unterstützen die Gültigkeit der STH-Hypothese nicht: Von sechs getesteten Probanden wies nur ein Proband eine zufällige Verteilung der semantischen Rollen auf. Die Fehlerrate für reversible Passivkonstruktionen im Tschechischen lag bei 33,34 % – dies entspricht einer überzufälligen Leistung der Probanden bezüglich der Zuordnung der semantischen θ-Rollen. Angesichts dieser Resultate muss die Validität der STH-Hypothese in Frage gestellt werden, und zwar auch im Hinblick auf die allgemeine Entwicklung der generativen Theorie., Andrea Hudousková, Eva Flanderková, Barbara Mertins, Kristýna Tomšů., and Obsahuje seznam literatury
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

8137. Hypoxia-induced pulmonary vascular remodeling: contribution of the adventitial fibroblasts

Creator:
Stenmark, K. R., Bouchey, D., Nemenoff, R., Dempsey, E. C., and Das, M.
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, hypoxie, proteinové kinázy, růstové faktory, plicní hypertenze, hypoxia, protein kinases, growth factors, pulmonary hypertension, vascular remodeling, smooth muscle cells, mitogen-activated protein kinase, protein kinase C, extracellular matrix, tyrosine kinase, 14, and 612
Language:
English
Description:
a1_Vascular repair in response to injury or stress (often referred to as remodeling) is a common complication of many cardiovascular abnormalities including pulmonary hypertension, systemic hypertension, atherosclerosis, vein graft remodeling and restenosis following balloon dilatation of the coronary artery. It is not surprising that repair and remodeling occurs frequently in the vasculature in that exposure of blood vessels to either excessive hemodynamic stress (e.g. hypertension), noxious blood borne agents (e.g. atherogenic lipids), locally released cytokines, or unusual environmental conditions (e.g. hypoxia), requires readily available mechanisms to counteract these adverse stimuli and to preserve structure and function of the vessel wall. The responses, which were presumably evolutionarily developed to repair an injured tissue, often escape self-limiting control and can result, in the case of blood vessels, in lumen narrowing and obstruction to blood flow. Each cell type (i. e. endothelial cells, smooth muscle cells, and fibroblasts) in the vascular wall plays a specific role in the response to injury. However, while the roles of the endothelial cells and smooth muscle cells (SMC) in vascular remodeling have been extensively studied, relatively little attention has been given to the adventitial fibroblasts. Perhaps this is because the fibroblast is a relatively ill-defined cell which, at least compared to the SMC, exhibits few specific cellular markers. Importantly though, it has been well demonstrated that fibroblasts possess the capacity to express several functions such as migration, rapid proliferation, synthesis of connective tissue components, contraction and cytokine production in response to activation or stimulation., a2_The myriad of responses exhibited by the fibroblasts, especially in response to stimulation, suggest that these cells could play a pivotal role in the repair of injury. This fact has been well documented in the setting of wound healing where a hypoxic environment has been demonstrated to be critical in the cellular responses. As such it is not surprising that fibroblasts may play an important role in the vascular response to hypoxia and/or injury. This paper is intended to provide a brief review of the changes that occur in the adventitial fibroblasts in response to vascular stress (especially hypoxia) and the role the activated fibroblasts might play in hypoxia-mediated pulmonary vascular disease., K. R. Stenmark, D. Bouchey, R. Nemonoff, E. C. Dempsey, M. Das., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

8138. Hysteretic behaviour of phosphoenolpyruvate carboxylase from Panicum maximum

Creator:
Avilan, L.
Format:
print
Type:
model:internalpart and TEXT
Language:
Multiple languages
Description:
Phosphoenolpyruvate carboxylase isolated from Panicům maximum Jacq. leaf presented a hysteretic behaviour that resulted in a kinetical lag in the reaction progress curve. This lag depended on the concentration of etuiyme, total phosphoenolpyruvate (PEP) and total Mg2+. Through an analysis of these dependences it is suggested that the hysteresis is due to an association-dissociation process influenced by union, to one form of the enzyme, of more than one of the three possible ligands; free Mg2+, free PEP or PEP-Mg2+ complex. The partially purified enzyme showed, during steady statě, a Michaelis-Menten kinetics for PEP and Mg2+ (total concentrations) and pH optima between 7.8 and 8.2.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

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