Hematopoiesis-modulating action of meloxicam, a cyclooxygenase-2 inhibitor, has been evaluated in mice. Increased serum level of granulocyte colony-stimulating factor (G-CSF) after meloxicam administration has been found in sublethally γ-irradiated animals. In further experiments hematopoiesis-stimulating effects of meloxicam and G-CSF given alone or in combination have been investigated. Granulocyte/macrophage progenitor cells counts were used to monitor these effects. Meloxicam and exogenous G-CSF did not act synergistically when given in combination, but could be mutually substituted during their repeated administration. The results suggest a promising possibility of using meloxicam as an auxiliary drug reducing the high costs of G-CSF therapy of myelosuppression., M. Hofer, M. Pospíšil, V. Znojil, J. Holá, A. Vacek, D. Štreitová., and Obsahuje bibliografii a bibliografické odkazy
The aim of this paper is to point out that the growing need for well‐educated citizens in the increasingly bureaucratized 18th Century, in itself a wellknown phenomenon, should be seen in a wider context. First, we must consider how it relates to the gradual emergence of the modern European nationstate; and secondly, to the cultural and political consequences of social stratification. In nations with a cohesive social structure and, in some cases, a tradition of statehood, the growing numbers and importance of the new intelligentsia were primarily the result of an expansion of existing elites drawing on their own social class. In emerging nations formed largely through nationalist movements, on the other hand, the process was accompanied by the upward mobility of young men from the middle and lower middle classes. In some nations, such as the Czechs and the Finns, these were often the sons of petit bourgeois and artisan families; but in the majority of cases the emergent national intelligentsia found its recruits chiefly among farmers and the rural population as a whole (Lithuania, Estonia). Understandably, this distinction led to differences in the formation of national stereotypes, political cultures and attitudes to social organization. The use of the term "plebeian intelligentsia" in this context is meant as a typological characteristic rather than a pejorative label., Miroslav Hroch., and Obsahuje bibliografické odkazy
Animal-free set-up enables a new series of experiments; from basic research describing trophic dependences of ticks to testing anti-tick compounds. Exploiting the cunning use of silicone membrane to mimic a host skin, in combination with perfumes that resemble the scents of a living animal, scientists from the Institute of Parasitology of the Biology Centre of the CAS gradually reveal what makes the tick a parasite. The membrane system is also intended for applied research, for testing anti-tick vaccines/compounds. and Jan Perner, Matěj Kučera, Petr Kopáček.
This study aims to interpret Mencius' political thinking taking as the starting point his doctrine of human nature. Each individual is capable of the moral self-cultivation of his or her innately good human nature, but in this task the individual requires adequate conditions and education. Political power is able to ensure this (and it is, indeed, one of its main asks to do so), but it can also, on the contrary, contribute, in a fundamental way, to the decadence of the state and society. The result of inadequate and ineffective application of political power is a growing crisis in society, especially in the area of inter-personal relations and moral conduct. Mencius' ideal is a relatively small and effective state that looks after its inhabitants and which does not unduly intervene in the social organism. War is understood, by him, as a great evil which is justifiably used only when putting-down an uprising or in self-defence. Generally, Mencius' political thought is characterized by the thought that the virtuous ruler will have, by dint of his strength of character, not only spiritual but also purely practical political successes., Stanislav Myšička., and Obsahuje poznámky a bibliografii