Unikátní vakcína pro léčbu infekčních onemocnění, historicky první zdokumentování vývoje zubu, které může pomoci v boji proti rakovině, revoluční objev organismu bez mitochondrií neboli „buněčných elektráren“ -i takové jsou aktuální výsledky vědeckých týmů z centra BIOCEV, které za účasti významných hostů zahájilo 16. června 2016 plný provoz., A unique vaccine to treat infectious diseases, tooth development documented the first time in history that might help fight cancer and the revolutionary discovery of an organism without mitochondria, referred to as “cell power plants”. These are some of the current results from the BIOCEV research teams. The centre’s full operation was officially launched on June 16, 2016 in the presence of Czech and foreign guests from different areas of science and politics. The Biotechnology and Biomedicine Centre of the Academy of Sciences and Charles University in Vestec (BIOCEV) was established with substantial financial aid from the European Union. By 2020, 400 researchers and 200 master’s degree as well as postgraduate students are expected to work there. As of today, 56 research groups under five synergic research programmes are focused on obtaining more detailed understanding of organisms at the molecular level. Their results are oriented towards applied research and the development of new medical procedures to combat severe health problems., Isd., and Autor je podepsaný šifrou Isd.
Representatives of the Academy of Science of Czech Republic and Charles University have subscribed to the Founding Contract of the Biotechnological and Biomedical Center (BIOCEV) that will be situated in the vicinity of Vestec. and Luděk Svoboda.
ECM is composed of different collagenous and non-collagenous proteins. Collagen nanofibers play a dominant role in maintaining the biological and structural integrity of various tissues and organs, including bone, skin, tendon, blood vessels, and cartilage. Artificial collagen nanofibers are increasingly significant in numerous tissue engineering applications and seem to be ideal scaffolds for cell growth and proliferation. The modern tissue engineering task is to develop three-dimensional scaffolds of appropriate biological and biomechanical properties, at the same time mimicking the natural extracellular matrix and promoting tissue regeneration. Furthermore, it should be biodegradable, bioresorbable and non-inflammatory, should provide sufficient nutrient supply and have appropriate viscoelasticity and strength. Attributed to collagen features mentioned above, collagen fibers represent an obvious appropriate material for tissue engineering scaffolds. The aim of this minireview is, besides encapsulation of the basic biochemical and biophysical properties of collagen, to summarize the most promising modern methods and technologies for production of collagen nanofibers and scaffolds for artificial tissue development., L. Koláčná, J. Bakešová, F. Varga, E. Košťáková, L. Plánka, A. Nečas, D. Lukáš, E. Amler, V. Pelouch., and Obsahuje bibliografii
In five genotypes of cowpea (Vigna unguiculata), the influence of salicylic acid (SA) on photosynthetic activity and biochemical constituents including peroxidase activity at the genotypic level was determined. After SA treatment the total free sugar content increased in IFC 8401 and IGFRI 450 genotypes, whereas the content of total leaf soluble proteins decreased significantly in IFC 902. The high chlorophyll (Chl) (a + b) content in IFC 902 showed a good correlation with the net photosynthetic rate (PN), as in this genotype a significant increase in PN was found after the SA treatment. and Amaresh Chandra,, R. K. Bhatt.
The well-known bottleneck of systems pharmacology, i. e., systems biology applied to pharmacology, refers to the model parameters determination from experimentally measured datasets. This paper represents the development of our earlier studies devoted to inverse (ill-posed) problems of model parameters identification. The key feature of this research is the introduction of control (or periodic forcing by an input signal being a drug intake) of the nonlinear model of drug-induced enzyme production in the form of a system of ordinary differential equations. First, we tested the model features under periodic dosing, and subsequently, we provided an innovative method for a parameter estimation based on the periodic dosing response measurement. A numerical example approved the satisfactory behavior of the proposed algorithm.
Spinal cord injury results in a permanent neurological deficit due to tissue damage. Such a lesion is a barrier for “communication” between the brain and peripheral tissues, effectors as well as receptors. One of the primary goal s of tissue engineering is to bridge the spinal cord injury and re-establish the damaged connections. Hydrogels are biocompatible implants used in spinal cord injury repair. They can create a permissive environment and bridge the lesion cavities by providing a scaffold for the regeneration of neurons and their axons, glia and other tissue elements. The advantage of using artificial materials is the possibility to modify their physical and chemical properties in order to develop the best implant suitable for spinal cord injury repair. As a result, several types of hydrogels have been tested in experimental studies so far. We review our work that has been done during the last 5 years with various types of hydrogels and their applications in experimental spinal cord injury repair., A. Hejčl, P. Lesný, M. Přádný, J. Michálek, P. Jendelová, J. Štulík, E. Syková., and Obsahuje bibliografii a bibliografické odkazy
State-of-the-art in bioelectrodynamics is presented. The brief review starts with introduction to the topic and definition of field followed by a short historical overview of bioelectrodynamics. Special attention is then paid to specific hot topics in this branch of biophysics, namely the ultra-weak photon emission from biological systems and radio-frequency electromagnetic field coupled to normal modes of microtubules. and Je shrnut stav problematiky v oboru bioelektrodynamiky. Stručný přehledový článek začíná úvodem do tématu a definicí oboru a je následován historickým přehledem bioelektrodynamiky. Speciální pozornost je poté věnována aktuálním tématům v tomto oboru biofyziky, jmenovitě ultraslabé fotonové emisi z biologických systémů a radiofrekvenčním elektromagnetickým polím spojeným s vlastními módy mikrotubulů.
Biofeedback is a treatment technique in which people are trained to improve their physiological functions by using different signals from their own bodies, e.g. from skin, heart (ECG), muscles (EMG), brain (EEG) etc. Psychotherapeutists use it to decrease intrapsychic tension in anxious and depressive patients and epileptics or learn to relax boys who suffered from attention deficit and hyperactivity disorders. The main system for consciousness (thalamocortical reverberation circuit) generates whole brain electromagnetic frequencies permanently (1-30 Hz = EEG activity). But we choose a specific frequency band, e.g. SMR (Sensory Motor Rhythm = 13-18 Hz) and these SMR episodes are rewarded by success in a simultaneously watched TV game. SMR is then repeated still more often and brings into electrogenesis and into psyche tendency its own property, which is motor inhibition and increasing attention. This is the aim of the therapeutical learning process.