Still's disease is an inflammatory disorder of unknown etiology. First-line therapy is based on corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) but the frequency of relapses and corticosteroid-induced adverse events are limiting factors. The efficacy of intravenous tocilizumab (TCZ) has been shown at a dose of 8 mg/kg but the corticosteroid-sparing effect of intravenous low-dose TCZ followed by subcutaneous (SC) injection in the course of the disease has been poorly investigated. We report the case of a 28-year old Caucasian woman presenting a relapse of Still's disease eleven months after diagnosis under treatment with 6 mg of methylprednisolone. TCZ at a dose of 4 mg/kg every 2 weeks was combined with 32 mg of methylprednisolone, followed by 162 mg SC every 3 weeks. Evolution was rapidly favourable with a decrease in corticosteroid doses. We reviewed previously published cases. and X. Vandemergel, F. Vandergheynst
The present article describes two unrelated cases of progressive myoclonic epilepsy (PME) of the Lafora's disease and Unverricht-Lundborg types who were treated with topiramate (TPM) as add-on therapy for their myoclonus. After the initiation of topiramate therapy both cases responded with marked decrease in myoclonic seizure frequency and improvement of quality of life. Topiramate appears to be a useful alternative agent in cases of PME and could be consider for adjunctive therapy. and CF. Demir, HH. Ozdemir, B. Müngen
BACKGROUND: A few reports demonstrate the occurrence of egg allergy in adolescent and adult patients suffering from atopic dermatitis and the association of this allergy to other food and aeroallergens. AIMS AND OBJECTIVES: The aim of this study is to evaluate the occurrence of egg allergy in patients suffering from atopic dermatitis at the age 14 years and older and to evaluate the relationship between egg allergy or egg sensitisation and the sensitisation to dust, mites, feather, and animal dander. MATERIALS AND METHODS: Complete dermatological and allergological examination was performed. These parameters were examined: food allergy and food sensitisation to egg white and yolk, to mites, animal dander (mixture), feather and dust. The statistical evaluation of the relations among egg allergy, egg sensitisation and sensitisation to mites, animal dander (mixture), feather and dust was performed. Two hundred and eighty eight patients were included in the study (90 men, 198 women, with the average age 25.2). RESULTS AND CONCLUSION: Egg allergy was recorded in 5% and egg sensitisation in 20% of patients; sensitisation to dust is recorded more often in patients with positive results in sIgE for egg white and/or yolk. and J. Čelakovská, K. Ettlerová, K. Ettler, J. Bukač
Female hybrids of the cross Chironomus t. thummi female × Ch. t. piger male which are largely affected by the sterility inducing Rud syndrome were backcrossed with males of both parental strains. The aim of the study was to provide information about those egg volumes that are insufficient for a normal embryogenesis and to ascertain whether in the hybrids the lethally small egg size represents a new abnormal trait of the Rud syndrome. The egg masses obtained contain eggs of very different sizes with volumes ranging from 0.5 nl to 3.49 nl. Embryo mortality is unusually frequent in those eggs of the backcrosses and of the parental strains that have volumes smaller than 1.5 nl. An egg volume of 1.5 nl represents in Ch. thummi the lower limit for those volumes that are sufficient for a normal embryogenesis. Mortality increases with decreasing egg size, reaching 100% in backcross eggs with volumes of 0.99 nl and smaller. Small egg size is a new trait of the Rud syndrome affected thummi female × piger male hybrids. This trait is part of a postzygotic reproductive isolation barrier between thummi and piger and manifests first in the backcrosses. Most backcross eggs show volumes between 1.5 nl and 2.99 nl. Within this volume range the amount of mortality does not depend upon egg volume. Here, embryo death is great in the backcrosses but normal in the parental strains. The high frequency of embryo death in the backcrosses must be predominantly due to the action of the Rud syndrome and a second hybrid syndrome, called HLE syndrome. Since further characteristic traits of these syndromes could be detected in surviving backcross individuals, the study demonstrates the occurrence of the syndromes in this generation also. Therefore, the postzygotic reproductive isolation mechanism of both hybrid syndromes is effective in the hybrids and in their progeny as well., Klaus Hägele, Monika Kasper-Sonnenberg, 4 obrázky, 2 tab., and Lit.
The half-popular compositions traditionally referred to as broadside ballads are a specific type of source. Some of them reflect Biblical, legendary and historical events in Egypt and the Near East. Although the factual importance of such ballads in not great, they have some informative value, because their texts mirror the attitudes and opinions of the lower social classes, in this case clearly influenced by the antithesis of Christianity and Islam, or also Judaism. They show that the authors of broadside ballads kept alive deep-rooted stereotypes, mainly the stereotype of Turks as pagans and tyrants. and Michal Klacek.
praktisch dargestellt von Emil André, Chybné stránkování, chybí s. 71 a 77-78, dvě s. označeny jako s. 73, Tištěno švabachem, and Converted from MODS to DC version 1.8 (EE patch 2018/05/24)