Efficacy of low-dose tocilizumab on relapsing adult-onset still's disease

Title:

Efficacy of low-dose tocilizumab on relapsing adult-onset still's disease
Efficacy of low-dose tocilizumab on relapsing adult-onset still's disease

Creator:

Vandemergel, Xavier and Vandergheynst, Frédéric

Contributor:

Vandemergel, Xavier and Vandergheynst, Frédéric

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:bmc16022583-9d1ecc29-b03d-416b-bd71-d212ff6f8b69
uuid:bmc16022583-9d1ecc29-b03d-416b-bd71-d212ff6f8b69
local:bmc16022583
http://actamedica.lfhk.cuni.cz/
doi: 10.14712/18059694.2016.51
local: bmc16022583

Subject:

dospělí, antiflogistika--terapeutické užití, monoklonální protilátky humanizované--aplikace a dávkování--terapeutické užití, antirevmatika--aplikace a dávkování--terapeutické užití, vztah mezi dávkou a účinkem léčiva, kombinovaná farmakoterapie, ženské pohlaví, glukokortikoidy--terapeutické užití, lidé, methylprednisolon--terapeutické užití, recidiva, Stillova nemoc - počátek v dospělosti--farmakoterapie, and výsledek terapie

Type:

model:article, article, Text, kazuistiky, časopisecké články, and TEXT

Format:

print, text, and regular print

Description:

Still's disease is an inflammatory disorder of unknown etiology. First-line therapy is based on corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) but the frequency of relapses and corticosteroid-induced adverse events are limiting factors. The efficacy of intravenous tocilizumab (TCZ) has been shown at a dose of 8 mg/kg but the corticosteroid-sparing effect of intravenous low-dose TCZ followed by subcutaneous (SC) injection in the course of the disease has been poorly investigated. We report the case of a 28-year old Caucasian woman presenting a relapse of Still's disease eleven months after diagnosis under treatment with 6 mg of methylprednisolone. TCZ at a dose of 4 mg/kg every 2 weeks was combined with 32 mg of methylprednisolone, followed by 162 mg SC every 3 weeks. Evolution was rapidly favourable with a decrease in corticosteroid doses. We reviewed previously published cases. and X. Vandemergel, F. Vandergheynst

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Relation:

Acta medica (Hradec Králové) Universitas Carolina, Facultas Medica Hradec Králové--MED00010947

Source:

Acta medica (Hradec Králové) | 2016 Volume:59 | Number:1

Harvested from:

CDK

Metadata only:

false

Date:

2016