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2522. Ash characteristic in co - combustion of coal with wood residue, sewage sludge and municipal waste
- Creator:
- Vladimír Tomášek, Ondřej Šustai, Jana Seidlerová, Zdeněk Klika, Stach, Martin, Zdeněk Weiss, and Václav Roubíček
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Geologie. Meteorologie. Klimatologie, uhlí, popílky, skenovací elektronová mikroskopie, coal, fly ash, scanning electron microscopy, bottom ash, X-ray microanalysis, 7, and 551
- Language:
- English
- Description:
- Samples of bottom ash and fly ash coming from the combustion of lignite with the addition of limestone, from the cocombustion of lignite and wood residue with limestone and from co-combustion of lignite, wood residue, biological sludges from the waste water treatment plant and municipal waste as well with the addition of limestone were examined. Scanning electron microscopy with X-ray microanalyser were used for study of morphology and chemical composition of ash particles. The results were compared with average composition of bottom ashes, fly ashes and input materials found by X-ray fluorescence spectrometry and with phase composition found by X-ray diffraction method. There were proved no significant differences in the character and the structure of individual samples coming from various regimes of combustion., Vladimír Tomášek, Ondřej Šustai, Jana Seidlerová, Zdeněk Klika, Martin Stach, Zdeněk Weiss and Václav Roubíček., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
2523. Ashe P., O´Connor J.P. & Murray D.A.: A checklist of Irish aquatic insects
- Creator:
- Soldán, T.
- Type:
- article, model:article, and TEXT
- Language:
- English
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2524. Asher, R. E., Annamalai, E., Colloquial Tamil. The Complete Course for Beginners
- Creator:
- Vacek, Jaroslav
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Language:
- English
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2525. Asiatic acid induces mitochondrial apoptosis via inhibition of JAK2/STAT3 signalling pathway in human osteosarcoma
- Creator:
- Yan, B. F., Chen, X., Liu, J., Liu, S. J., Zhang, J. Z., Zeng, Q. Q., and Duan, J. A.
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- osteosarcoma, asiatic acid, mitochondrial apoptosis, and JAK2/STAT3/MCL-1
- Language:
- English
- Description:
- Osteosarcoma (OS), a severe malignant bone tumour, usually occurs in adolescents and children and has a poor prognosis. Asiatic acid (AA), an active component isolated from Centella asiatica (L.) Urb., exhibits appreciable anti-oxidant and anti-tumour activities. So far, the effects and underlying mechanisms of AA against OS have not been clarified. Here, we explored the anti-tumour effects of AA against human OS and the involved mechanism mediating its actions. To evaluate effects of AA on the cell proliferation of human OS cells, cell viability and colony formation assays were performed. Flow cytometry was used to evaluate apoptosis in OS cells exposed to AA and mitochondrial membrane potential. Western blotting and RT-PCR were applied to determine expression of the relevant proteins and their mRNA levels. Our explorations showed that AA inhibits proliferation of human OS cells in a concentration- and time-dependent manner, and induces apoptosis of OS cells by the intrinsic (mitochondrial) pathway. Importantly, we found that inhibition of the AA-induced phosphorylation of JAK2/STAT3 signalling molecules and the decrease in MCL-1 contributed to the anti-tumour efficacy of AA. Collectively, our results suggest that AA could evoke mitochondrial- induced apoptosis in human OS cells by suppression of the JAK2/STAT3 pathway and MCL-1 expression. These results strongly demonstrate that AA could be a potential anti-tumour agent for OS treatment.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
2526. ASIC1a involves the acid-mediated activation of pancreatic stellate cells associated with autophagy induction
- Creator:
- Wang, Tao, Wang, Qianqian, Pan, Guixia, Jia, Guorong, Li, Xiao, Wang, Chao, Zhang, Liming, and Zuo, Changjing
- Format:
- počítač and online zdroj
- Type:
- model:article and TEXT
- Subject:
- ASIC1a, pancreatic stellate cells, activation, autophagy, and acidosis
- Language:
- English
- Description:
- The acidic tumor microenvironment (TME) of pancreatic cancer affects the physiological function of pancreatic stellate cells (PSCs), which in turn promotes cancer progression. Acid-sensing ion channel 1a (ASIC1a) is responsible for acidosis-related physiopathological processes. In this study, we investigated the effect of acid exposure on the activation and autophagy of PSCs, and the role of ASIC1a in these events. The results showed that acidic medium upregulated the expression of ASIC1a, induced PSCs activation and autophagy, which can be suppressed by inhibiting ASIC1a using PcTx1 or ASIC1a knockdown, suggesting that ASIC1a involves these two processes. In addition, the acidinduced activation of PSCs was impaired after the application of autophagy inhibitor alone or in combination with ASIC1a siRNA, meaning a connection between autophagy and activation. Collectively, our study provides evidence for the involvement of ASIC1a in the acid-caused PSCs activation, which may be associated with autophagy induction.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
2527. Asimilace jako příklad mezijazykového kontrastu: čeština vs. holandština
- Creator:
- Rechzieglová, Adéla
- Format:
- Type:
- model:internalpart and TEXT
- Language:
- Czech and English
- Description:
- In this paper I have introduced one case of modification of articulation at the word-boundary, i. e. the assimilation, which regularly takes place in Dutch, but is impeded in Czech. In Dutch the assimilation of [s] in front of [j] is the result of coarticulation, applied in order to reduce the articulatory effort. It is, however, not an isolated phenomenon, but it is connected with the not clearly defined phonological and phonetic opposition of [s] and [š]. In Czech, despite the presumption that the coarticulation of the [s] in front of [j] also is possible, it is not audible for the speakers as modification, and - most importantly - it does not yield assimilation of the former to the latter, i. e. the realization of [š]. In our opinion the constraints are complex, in the first place we should point to the distinctive role of the /s/ and /š/ in the whole system. The perceptual segmentation in Czech, moreover, is ruled by the distribution of word-stress at the initial syllable of the word (after a pause); this brings about the hyperarticulation of the syllable, so that no need is felt to reduce the articulation. Because of the typological difference between Czech and Dutch, as respectively inflective and not-inflective languages, the phonetic phenomena at the word-end can be very significant and should be examined further.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
2528. Asistovaná reprodukce a věk
- Creator:
- Konečná, Hana
- Format:
- electronic, electronic resource, and remote
- Type:
- model:article, article, Text, and TEXT
- Language:
- Czech and English
- Description:
- Medicínské technologie dokáží udělat rodiče i z člověka v pozdním seniu. Odborné debaty se soustřeďují nejen na to, jaké metody asistované reprodukce jsou eticky přijatelné, ale i na to, pro jaké skupiny lidí a za jakých okolností jsou přijatelné. Moje analýza je inspirována úmyslem státních orgánů a) zvýšit věkovou hranici pro přístup k léčbě placené ze zdravotního pojištění (ZP), b) zvýšit počty cyklů placených ze ZP; c) zrušit zákonem danou horní věkovou hranici pro samoplátce. Pro rozsáhlost tématu je text rozdělen do dvou samostatných článků. V této první části analyzuji věk pro platbu léčby ze ZP, relevantní argumenty nacházím pouze pro platbu léčby ženám do 40 let., Medical technology can make parents from persons in their late senium. Bioethical debates focus not only on what methods of assisted reproduction are ethically acceptable, but also for which of group of people and under what circumstances are they acceptable. My analysis is inspired by the intention of government a) to increase the age for access to treatment paid by health insurance (HI), b) to increase the number of cycles paid by HI, c) to abolish the upper age limit, given by law, for paying cash. The analysis is divided into two separate articles, because the topic is very broad. In this first part I analyze the age limit for payment of treatment by HI, I find relevant arguments onlxy for payment of treatment to women up to 40 years., Hana Konečná, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2529. Asistovaná reprodukce a věk
- Creator:
- Konečná, Hana
- Format:
- electronic, electronic resource, and remote
- Type:
- model:article, article, Text, and TEXT
- Language:
- Czech and English
- Description:
- Druhá část do dvou článků rozdělené analýzy věkových limitů v asistované reprodukci (ART). V této části se zaměřuji na hledání věkových limitů pro přístup k ART u samoplátců, zvažuji přitom zájmy čtyř z pěti zúčastněných členů systému: žadatele/lů o léčbu, dárce gamet, budoucího dítěte a společnosti, a rizika s tím spojená. Pro potvrzení současné zákonné věkové hranice pro ženu (den před 50. narozeninami) ani pro její zvýšení či odstranění nenacházím dostatečné důvody. Naopak se domnívám, že by měla být určena věková hranice i pro muže., The second part of analysis of age limits in assisted reproductive technology (ART), divided into two articles. In this section, I focus on defining age limits for access to ART for self-payers, I am considering the interests of four of the five participating members of the systém: ART applicant/s, gametedonor/s, child to-be-born, society, and the associated risks. I did not find sufficient grounds to confirm the current legal age limit for women (the day before the 50th birthday), nor for the increase or the elimination of the limit. On the contrary, I believe that should be addressed age limit for men., Hana Konečná, and Literatura
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2530. Asociace aterotrombózy a trombofilie – genetické aspekty
- Creator:
- Kvasnička, Tomáš
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, přehledy, práce podpořená grantem, and TEXT
- Subject:
- lidé, srovnávací asociační studie genomů, genetická predispozice k nemoci, polymorfismus jednoho nukleotidu, trombofilie--genetika, žilní tromboembolie--genetika, infarkt myokardu--genetika, ischemická choroba srdeční--genetika, trombóza--genetika, genetické lokusy--genetika, cévní mozková příhoda--genetika, lokus kvantitativního znaku, aterotrombóza, jednonukleotidový polymorfizmus, and celogenomové asociace (GWAS)
- Language:
- Czech and English
- Description:
- Vzniku trombózy v arteriálním nebo venózním cévním systému předchází složitá souhra faktorů vnějšího prostředí a faktorů genetických. Rozsáhlé genomové asociační studie se ukazují jako velice přínosné v identifikaci lokusů spojených s kardiovaskulárními onemocněními a souvisejícími rizikovými faktory. Ještě zbývá mnoho práce v identifikaci určujících genů a jejich kauzálních variant, stejně jako v definici mechanizmů, které ovlivňují vývoj a progresi onemocnění. Z výsledků studií lokusů spojených s dříve identifikovanými onemocněními se očekává zlepšení našich znalostí o patofyziologii kardiovaskulárních onemocnění a možnost identifikovat nové cíle pro léčbu. V oblasti aterotrombózy a trombofilie jsou významné výsledky z asociačních studií zaměřených na oblast ischemické choroby srdeční, ischemické cévní mozkové příhody a žilního tromboembolizmu. Klíčová slova: ateroskleróza – aterotrombóza – celogenomové asociace (GWAS) – infarkt myokardu – ischemická choroba srdeční – jednonukleotidový polymorfizmus (SNP) – trombofilie – žilní tromboembolizmus, Thrombosis in the arterial or venous vascular systems is preceded by a complex interplay between environmental and genetic factors, and it is the underlying cause of several common complex diseases. The genomewide association approach has proved successful in identifying loci associated with cardiovascular disease and related risk factors. However, much work remains to identifyning the culprit genes and causal variants as well as the mechanisms whereby they influence disease development and progression. In-depth studies of previously identified disease-associated loci are expected to improve our understanding of the pathophysiology of cardiovascular disease and identify novel targets for treatment. In the field of atherothrombosis and thrombophilia are significant results from association studies focused on the area of coronary artery disease, ischemic stroke, venous thromboembolism. Key words: atherosclerosis – atherothrombosis – coronary artery disease – genomewide association study (GWAS) – myocardial infarction – single nucleotide polymorphism (SNP) – thrombophilia – venous thromboembolism, and Tomáš Kvasnička
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public