Search

Start Over Language English Harvested from CDK

3162. Borrelia burgdorferi in a focus of Lyme borreliosis: epizootiologic contribution of small mammals

Creator:
Humair, P.S., Turrian, N., Aeshlimann, A., and Gern, L.
Format:
print
Type:
model:internalpart and TEXT
Subject:
Ixodes ricinus, Borrelia burgdorferi, Lyme borreliosis, small mammals, infectivity potential, seasonality, and epizoo tiology
Language:
English
Description:
The contribution of woodiniee (Apodemus sylvaticus), yellow-necked mice (Apodemus flavicollis) and bank voles (Clethrionomys glareolus) was compared in a focus of Lyme borreliosis in Switzerland during a 7 months’ study. All three species of mice and one species of shrews (Sorex araneus) were shown parasitized by infected Ixodes ricinus immatures. About 14% of larvae and 50% of nymphs collected on small mammals were infected with B. burgdorferi. Spirochetes were isolated from blood of 3 woodmice and one yellow-necked mouse. The infectious status of rodents was estimated by tick xenodiagnosis. Prevalence of infected rodents ranged from 20% to 44%. Mice presented a higher potential infectivity than voles. The prevalence of infected rodents showed a seasonal variation.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3164. Borrelia-infection rates in tick and insect vectors accompanying human risk of acquiring Lyme borreliosis in a highly endemic region in Central Europe

Creator:
Zeman, Petr
Format:
print
Type:
model:internalpart and TEXT
Subject:
Lyme borreliosis, retrospective epidemiological data, statistical mapping, arthropod vectors, direct immunofluorescence assay, correlation, Central Bohemia, and geographical information system (GIS)
Language:
English
Description:
The methods of spatial statistics were applied to assess the geographical pattern of risk of Lyme borreliosis in Central Bohemia, the Czech Republic, based on retrospective data on disease contractions. The statistical risk was then compared at 15 selected localities with the infection challenge presented by ticks and insects carrying borreliae. Over 5,000 Ixodes ricinus (L.) ticks and 390 hacmatophagous dipterans were screened by direct immunofluorescence method, and the spatial and seasonal variance of infection rates were studied. Infected ticks were found at each locality throughout the warm season; in nymphs, sample infection rates ranged from 4.9% to 23.1% with a mean of 14.5% in spring, from 7.7% to 28.7% with a mean of 16.1% in summer, and from 7% to 20.6% with a mean of 13.6% in autumn. The statistical risk was found to correlate well with an average nymphal infection challenge, i.e. I. ricinus nymphal abundance x infection rate, at a given locality. Statistically significant cumulation of insect-history recalling patients into several, generally wetland, areas was ascertained; borreliae were revealed in 0.5% of the dipterans examined.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3165. Bosentan normalizes the GFR response to renal nerve stimulation following reversible unilateral ureteric obstruction in the rat

Creator:
Hammad, F. T., Wheatley, A. M., and Davis, G.
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, ureteric obstruction, renal nerve stimulation, bosentan, 14, and 612
Language:
English
Description:
We investigated the renal response to direct renal nerve stimulation, 2 weeks following reversal of 24-h unilateral (left) ureteric obstruction. Renal nerve stimulation caused a 13-15 % fall in renal blood flow, in 4 groups of anesthetized rats following ureteric obstruction (n=9) or a sham operation (n=7) both with (n=9) and without (n=7) treatment with the mixed ETA/B receptor antagonist, bosentan. In the sham-operated rats, renal nerve stimulation did not change glomerular filtration rate but reduced urine flow rate (37±3 %, P<0.001), and absolute (38±4 %, P<0.001) and fractional (35±5 %, P<0.01) sodium excretion. Following unilateral ureteric obstruction, renal nerve stimulation increased glomerular filtration rate by 22±3 % (P<0.01), but reduced urine flow rate (14±2 %, P<0.001) and fractional sodium excretion (23±5 %, P<0.01). Bosentan treatment had no effect on baseline or renal responses to renal nerve stimulation in the sham group but normalized the renal response to renal nerve stimulation in the unilateral ureteric obstruction group. We conclude that 14 days after a 24-h period of unilateral ureteric obstruction there is an increase in GFR in response to direct renal nerve stimulation, which is due, in part, to the actions of endothelin at the time of obstruction., F. T. Hammad, A. M. Wheatley, G. Davis., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3166. Bosnian Study on Markers of Ischaemic Stroke in Adults 20–50 Years Old (SMISAO): preliminary report

Creator:
Mahmutbegovic, N., Mehicevic, A., Adler, G., Omerhodzic, I., Mahmutbegovic, E., Valjevac, A., Borecki, K., and Mehmedika Suljic, E.
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
stroke, young adults, risk factors, and SNPs
Language:
English
Description:
Previous research suggested that several genetic polymorphisms are associated with increased risk of ischaemic stroke (IS) in young adults. However, the predictive biomarkers of IS in young adults are still unclear. Our aim was to assess the contribution of modifiable and genetic factors in IS in young adults. In total, 40 stroke patients and 40 healthy controls aged 20 to 50 years were recruited. Data on modifiable factors were collected, then participants were genotyped for seven SNPs linked to thrombophilia: ACE rs1799752, PAI-1 rs1799889, APOE rs1412 and rs429358, FV rs6025 and rs1800595, and FII rs62623459. Significantly increased risk factors: hypertension and dyslipidaemia in stroke patients compared with the controls: 50.0 % vs 27.5 % and 75.0 % vs 40.0% (P = 0.039 and P = 0.002, respectively) were observed. Stroke patients compared with controls did not differ in distribution of ACE, APOE, FV, and FII variants. The 4G4G homozygotes of the PAI-1 gene were significantly more prevalent in stroke patients compared to the controls: 42.5 % vs 17.5 %, (P = 0.033). In the group with the small vessel occlusion subtype of stroke, statistically significant overrepresentation of 4G4G homozygotes and frequency of the 4G allele compared with controls: 57.1 % vs 17.5 % and 0.7 vs 0.45 (P = 0.026 and P = 0.03, respectively) were observed. Independent predictors of stroke incident were: dyslipidaemia (OR (95% CI) = 4.2 (1.4–12.4)) and 4G4G genotype (OR (95% CI) = 3.9 (1.1–13.7)). These results confirm the contribution of dyslipidaemia and 4G4G genotype in the increased risk of IS in young Bosnian adults.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3168. Both Caspase and Calpain are involved in endoplasmic reticulum-targeted BNIP3-induced cell death

Creator:
Zeng, J., Huang, Y. Y. , Xu, X. M., Li, S. H. , and Zuo, D. C.
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
BNIP3, cell death, endoplasmic reticulum, calpain, and caspase
Language:
English
Description:
Bcl-2/E1B-19K-interacting protein 3 (BNIP3) is a member of the apoptotic B-cell lymphoma-2 family that regulates cell death. Although BNIP3 targeted normally to the mitochondrial outer membrane by its transmembrane domain was originally considered to be essential for its pro-apoptotic activity, accumulating evidence has shown that BNIP3 is localized to endoplasmic reticulum at physiological conditions and that forced expression of BNIP3 can initiate cell death via multiple pathways depending on the subcellular compartment it targets. Targeting BNIP3 to endoplasmic reticulum has been shown to participate in cell death during endoplasmic reticulum stress. However, the molecular events responsible for BNIP3-induced cell death in the endoplasmic reticulum remain poorly understood. In the present study, the transmembrane domain of BNIP3 was replaced with a segment of cytochrome b5 that targets BNIP3 into endoplasmic reticulum, which induced cell death as effectively as its wild-type molecule in the SW480 cell line (colon carcinoma). Furthermore, a pan-caspase inhibitor, z-VAD-fmk, and PD150606, a specific calpain inhibitor, both significantly suppressed the endoplasmic reticulum-targeted BNIP3- induced cell death. These results suggest that endoplasmic reticulum-targeted BNIP3 induced a mixed mode of cell death requiring both caspases and calpains.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

3169. Both water intoxication and osmotic BBB disruption increase brain water content in rats

Creator:
Petr Kozler, Vladimír Riljak, and Pokorný, J.
Format:
print
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, mozek, brain, brain water content, brain edema, osmotic BBB disruption, water intoxication, locomotor activity, 14, and 612
Language:
English
Description:
Our previous experiments revealed that water intoxication and osmotic BBB disruption in the rat allow penetration of high- molecular substances into the brain and that resulting changes in the internal environment of th e CNS lead to pathological development, such as the loss of integrity of myelin. The aim of the present study was to determine whether the previously described phenomena are associated with increased water content in the brain. To answer the question following methods were used: a) water intoxication : intraperitoneal administration of distilled water, b) osmotic BBB disruption: application of mannitol (20 %) selectively into the internal carotid artery, c) brain wet weight was measured after decapitation, and subsequently (after six days in thermostat set at 86 °C) the dry weight were estimated d) in animals with 20 % and 30 % hyperhydration the degree of myelin deterioration was estimated e) animal locomotor activity was tested by continuous behavior tracking and analysis. Brai n water content after water intoxication and following the administration of mannitol was higher than in the control group. Different degrees of hyperhydration led to different levels of brain water content and to different degrees of myelin impairment. Hyperhydration corresponding to 20 % of the body weight brought about lower locomotor activity. Increased water content in the brain after the BBB osmotic disruption is surprising because this method is frequently used in the clinical practice., P. Kozler, V. Riljak, J. Pokorný., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3170. Bothriocephalidean tapeworms (Cestoda) from the blackfish, Centrolophus niger (Perciformes: Centrolophidae)

Creator:
Kuchta, Roman, Scholz, Tomáš, Brabec, Jan, Jirsová, Dagmar, and Gustinelli, Andrea
Format:
bez média and svazek
Type:
model:article and TEXT
Subject:
Bothriocephalidea, species survey, Amphicotyle heteropleura, Bothriocotyle solinosomum, Echinophallus wageneri, Milanella familiaris, morphology, taxonomy, and identification key
Language:
English
Description:
Bothriocephalidean tapeworms parasitic in the blackfish, Centrolophus niger (Gmelin) (Perciformes: Centrolophidae), are redescribed on the basis of the evaluation of freshly collected specimens and museum material. This evaluation enabled us to supplement species diagnoses by new morphological characters of potential use for phylogenetic analyses, including the data from scanning electron microscopical observations, and to provide a key to identification of the following four species occurring in this fish: Amphicotyle heteropleura (Diesing, 1850); Milanella familiaris Kuchta et Scholz, 2008 (both Triaenophoridae); Bothriocotyle solinosomum Ariola, 1900; and Echinophallus wageneri (Monticelli, 1890) (both Echinophallidae). Large spiniform microtriches were observed on the surface of the posterodorsal margin of segments of B. solinosomum, E. wageneri and M. familiaris. The invalidity of Atelemerus Guiart, 1935, first proposed by Bray et al. (1994), is supported by the present data and its type species, A. acanthodes Guiart, 1935, is newly synonymised with E. wageneri.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

Limit your search

Show values starting with
more »

Show values starting with
more »

Show values starting with
more »

Show values starting with
more »

Show values starting with
more »

Show values starting with
more »

Show values starting with
more »

Show values starting with
more »

View distribution

Current results range from 1701 to 2023

View larger »