We investigated the effects of telmisartan, the blocker of angiotensin II receptor 1, on the regulation of systolic blood pressure (SBP) and oxidative stress through endothelial nitric oxide (NO) release in spontaneously hypertensive rats (SHRs). SHRs randomly received placebo, oral feeding of telmisartan (5 mg/kg or 10 mg/kg) every day and Wistar-Kyoto rats (WKYs) served as normotensive control. The SBP of rat was measured before and weekly thereafter. After a total of 8-week treatment, rats were killed for experimental measurements. Parameters that subject to measurements in isolated aorta endothelial cells include: NO concentration, protein expression levels of angiotensin II receptor 1, nitrotyrosine, 8-isoprostane, SOD, PI3K, Akt, AMPK and eNOS. In addition, L-NMMA, a general inhibitor of nitric oxide synthase, was also applied to test the inhibition of NO concentration. We found that SBPs were significantly lower in telmisartan therapy group than in placebo treated hypertensive rats and WKYs (p<0.05). The NO concentration was significantly higher in telmisartan-treated group with increased activity of the PI3K/Akt pathway and activated eNOS signaling. Blockade of Akt activity reversed such effects. Activation of AMPK also contributed to the phosphorylation of eNOS. L-NMMA treatment reduced less NO concentration in SHR rats than the telmisartan co-treated groups. Oxidative stress in SHRs was also attenuated by telmisartan administration, shown by reduced formation of nitrotyrosine, 8-isoprostane, and recovered SOD protein level. Telmisartan enhanced NO release by activating the PI3K/Akt system, AMPK phosphorylation and eNOS expression, which attenuated the blood pressure and oxidative stress in SHRs., L. Xu, Y. Liu., and Obsahuje seznam literatury
Let y be observation vector in the usual linear model with expectation Aβ and covariance matrix known up to a multiplicative scalar, possibly singular. A linear statistic aTy is called invariant estimator for a parametric function ϕ=cTβ if its MSE depends on β only through ϕ. It is shown that aTy is admissible invariant for ϕ, if and only if, it is a BLUE of ϕ, in the case when ϕ is estimable with zero variance, and it is of the form kϕˆ, where k∈⟨0,1⟩ and ϕˆ is an arbitrary BLUE, otherwise. This result is used in the one- and two-way ANOVA models. Our paper is self-contained and accessible, also for non-specialists.
Christian Hartmann, Thomas Vordermeyer, Othmar Plöckinger, and Roman Töppel (eds.). Hitler, Mein Kampf: Eine kritische Edition. Munich and Berlin: Institut für Zeitgeschichte, 2016, vols 1-2, 947 + 1019 pp., ISBN 978-3-9814052-3-1. With Edith Raim, Pascal Trees, Angelika Reizle, and Martina Seewald-Mooser. Includes illustrations, maps, a list of all known translations of Mein Kampf before 1945, a list of abbreviations, a detailed bibliography in three parts (before 1932, 1933-45, after 1945), and four indexes (a biographical index and indexes of persons, places, and subjects).In the form of an essay, the author comments here on the 2016 critical edition of Hitler’s Mein Kampf (1925-26), edited by a team of historians from the Institute of Contemporary History in Munich, with additional assistance from others. He contemplates the nature and importance of this book and discusses its author and his meaning in the history of twentieth-century central Europe. He then discusses some of the ideas of Mein Kampf, and clarifi es the historical context of the work, returning to the circumstances that led to its being written and published. He also discusses some of Hitler’s fellow travellers in the Nazi movement, who were of importance for this key work. The author brings up episodes in Hitler’s life, and pays particular attention to his still unclear transformation from an apolitical soldier into a zealous antisemite and political agitator of exceptional rhetorical skill, who was able to bewitch the German people and become their Führer. The author also discusses the diffi culties that the editors of this critical edition had to struggle with, and he praises their work as utterly solid and astonishingly thorough, particularly the commentaries in the huge critical apparatus. The author concludes by discussing reactions both to the fi rst edition of Mein Kampf and to this critical edition, and he discusses various attempts to publish a Czech edition.
Přeloženo z češtiny, Životopisná data, přehled výstav a zastoupení ve sbírkách, Chronologický přehled, and "This book is published on the occasion of the exhibition of the same name organised by the Gallery of the City Prague in corporation with Gallery, s.r.o., in the House At the Stone Bell and on the second floor of the Old Town Hall in Prague from 19 November 2004 to 20 February 2005"--Tiráž