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2832. Authors' index to volume 60
- Type:
- article and TEXT
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/
2833. Authors' index to volume 61
- Type:
- article, model:article, and TEXT
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
2834. Autism spectrum disorder is associated with autonomic underarousal
- Creator:
- Bujnakova, I., Ondrejka, I., Mestanik, M., Visnovcova, Z. , Mestanikova, A., Hrtanek, I., Fleskova, D., Calkovska, A., and Tonhajzerova, I.
- Type:
- article, model:article, and TEXT
- Subject:
- Autism spectrum disorder, Autonomic nervous system, Heart rate variability, and Electrodermal activity
- Language:
- English
- Description:
- Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder, associated with autonomic dysregulation. However, the pathomechanism leading to autonomic abnormalities is still unclear. The aim of this study was to assess autonomic nervous system (ANS) activity during baseline in homogenous group of autistic children using electrodermal activity (EDA), as an index of sympathetic activity and short -term heart rate variability (HRV) reflecting predominantly cardiac vagal control. Fifteen ASD boys and 15 healthy age-matched boys at the age of 7-15 years were examined. The continuous EDA and ECG were recorded during resting phase in a supine position. Evaluated parameters: EDA amplitude (μS), RR interval, spectral power, peak frequency and power spectral density in low (LF-HRV: 0.04-0.15 Hz) and high-frequency (HF-HRV: 0.15-0.4 Hz) bands of HRV spectral analysis. In ASD group we found significantly shortened RR intervals (729±20ms vs. 843±30 ms, p=0.005), lower mean EDA (0.66±0.13 μS vs. 1.66±0.42 μS, p=0.033), reduced spectral activity and power spectral density in HF-HRV compared to controls (2.93±0.12 ms2 vs. 3.38±0.10 ms2, p=0.01; 4.12±0.10 ms2/Hz vs. 4.56±0.11 ms2/Hz, p=0.008, respectively). We suggested that impairment in resting autonomic regulation associated with ASD could represent an important pathomechanism leading to potential cardiovascular complications in ASD.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2835. Autobiographies on the Occupation of Denmark 1940-45 in the Danish Historical Bibliography /
- Creator:
- Eklund-Jürgensen, Lene
- Type:
- text and studie
- Subject:
- Bibliografie. Katalogy, Mejslov, Ove,, bibliografie dánské, okupace nacistická, autobiografie, bibliografie, Dánsko, světové dějiny 1939-1945, and vojenské operace, války, bitvy
- Language:
- English
- Rights:
- unknown
2836. Autocrine effects of visfatin on hepatocyte sensitivity to insulin action
- Creator:
- Vojtěch Škop, Kontrová, K., Václav Zídek, Michal Pravenec, Ludmila Kazdová, Mikulík, K., Jiří Sajdok, and Jarmila Zídková
- Format:
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, inzulinová rezistence, RNA interference, insulin resistance, visfatin, fao hepatocytes, 14, and 612
- Language:
- English
- Description:
- Visfatin was originally described as an adipokine with insulin mimetic effects. Recently, it was found that visfatin is identical with the Nampt (nicotinamide phosphoribosyltransferase) gene that codes for an intra- and extracellular NAD biosynthetic enzyme and is predominantly expressed outside the adipose tissue. In the current study, we found strong protein and mRNA expression of visfatin in rat heart, liver, kidney, and muscle, while the expression of visfatin in visceral fat was significantly lower and undetectable in subcutaneous fat. The insulin-mimetic effects of visfatin (extracellular form of Nampt or eNampt) are controversial and even less is known about autocrine effects of visfatin (intracellular form of Nampt or iNampt). Since liver plays a major role in glucose metabolism, we studied visfatin effects on insulin-stimulated cellular glucose uptake in Fao rat hepatocytes using RNA interference (RNAi). RNAi-mediated downregulation of visfatin expression in Fao cells was associated with significantly reduced NAD biosynthesis (0.3±0.01 vs. 0.5±0.01 mmol/h/g, P<0.05) and with significantly decreased incremental glucose uptake after stimulation with insulin when compared to controls with normal expression of visfatin (0.6±0.2 vs. 2.2±0.5 nnmol/g/2 h, P=0.02). These results provide evidence that visfatin exhibits important autocrine effects on sensitivity of liver cells to insulin action possibly through its effects on NAD biosynthesis., V. Škop ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
2837. Autofluorescence in the oocyst of marine and freshwater fish coccidia
- Creator:
- Davies, Angela and Stewart, Barbara
- Format:
- Type:
- model:internalpart and TEXT
- Language:
- English
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
2838. Autoimmune Thyroid Diseases in Women with Breast Cancer and Colorectal Cancer
- Creator:
- Jiskra, J., Límanová, Z. , Barkmanová, J., Smutek, D., and Friedmannová, Z.
- Type:
- article, model:article, and TEXT
- Subject:
- Breast cancer, Thyroid autoantibodies, and Thyroid stimulating hormone
- Language:
- English
- Description:
- The aim of the study was to compare the prevalence of autoimmune thyroid diseases in three groups of women (66 with breast cancer (CaB), 68 with colorectal cancer (CaC) and 49 without oncological diseases as a control group). Serum levels of thyroid-stimulating hormone (TSH), free thyroxin (fT4), antibodies to thyroglobulin (TGB-ab) and thyroperoxidase (TPO-ab) and tumor markers CEA, CA 15-3 and CA 19-9 were investigated in all subjects by using the chemiluminiscence method. In contrast to Graves’ disease (no observed case), autoimmune thyroiditis was diagnosed in 24.2 % women with CaB (4.5 % euthyroid and 19.7 % with subclinical or overt hypothyroidism), compared to 16.7 % in women with CaC (2.0 % euthyroid and 14.7 % with subclinical or overt hypothyroidism) and 16.2 % controls (4.0 % euthyroid and 12.2 % with subclinical or overt hypothyroidism). Serum levels of TGB-ab were higher in the group with breast cancer as compared to those with colorectal cancer and the control group (medians: 35.80 vs. 31.75 vs. 27.70, p<0.001). Similarly, the percentage of positive TGB-ab and TPO-ab serum levels was higher in women with breast cancer as compared to those with colorectal cancer and the control group. The results of the study support the controversial theory that there is an increased prevalence of autoimmune thyroiditis in women with breast cancer.
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
2839. Automamatic detection of discontinuities in the station position time series of the reprocessed global GNSS network using bernese GNSS software
- Creator:
- Najder, Joanna
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- GNSS coordinates, time series analysis, discontinuity detection, velocity changes, station displacements, ITRF, FODITS, and JPL
- Language:
- English
- Description:
- For over 25 years, the International GNSS Service (IGS) has been processing observational data from the Global Navigation Satellite Systems (GNSSs). Hence, long time series of station coordinates are available, however, they are burdened with discontinuities, station velocity changes, and gross errors. Discontinuities and periodic variations are caused by equipment changes at stations, earthquakes, geophysical processes, data problems, as well as local environmental changes. As a result, many approaches have been identified that identify and remove discontinuities in the GNSS coordinate time series. One of them is the program Finding Outliers and Discontinuities In Time Series (FODITS) implemented in the Bernese GNSS Software environment (Dach et al., 2015), developed by the Astronomical Institute, University of Bern. The program is designed for the automatic analysis of time series, in which the functional model is adapted to the time series of coordinates depending on the adopted parameters. This study presents the analysis of long-term GNSS coordinate time series reprocessed in the framework of the realization of the International Terrestrial Reference Frame 2014 (ITRF2014) using the FODITS program. The results show that the optimum confidence level for the autonomous detection of station discontinuities in FODITS is 99% and 98%, for 7-day and 3-day GNSS solutions, respectively, when compared to the manual discontinuity detection from ITRF2014. However, the manual analysis unsupported by statistical tests as conducted in ITRF2014 may contain errors over which further elaboration is indispensable. On the other hand, routine interpretation of GNSS coordinate time series in a fully autonomous manner, although much faster, is not free from drawbacks, in particular in detecting appropriate epochs of discontinuities and changes in station velocities.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
2840. Automata with modulo counters and nondeterministic counter bounds
- Creator:
- Reidenbach, Daniel and Markus, L. Schmid
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- multi-head automata, counter automata, modulo counters, stateless automata, and restricted nondeterminism
- Language:
- English
- Description:
- We introduce and investigate Nondeterministically Bounded Modulo Counter Automata (NBMCA), which are two-way multi-head automata that comprise a constant number of modulo counters, where the counter bounds are nondeterministically guessed, and this is the only element of nondeterminism. NBMCA are tailored to recognising those languages that are characterised by the existence of a specific factorisation of their words, e. g., pattern languages. In this work, we subject NBMCA to a theoretically sound analysis.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public