Following the Article 16 (7) of the Directive 2000/60/EC of the European Parliament and of the Council establishing a framework for Community action in the field of water policy Commission shall submit proposals for environmental objectives applicable to the concentrations of the priority substances in surface water, sediments or biota. In the absence of agreement at Community level up to the deadline given by the directive Member States shall establish environmental objectives themselves. Within the framework of legislative preparation to this situation we have evaluated the relationships between particular parameters of surface water and total suspended solids contamination with heavy metals and with arsenic as one group of priority substances. Neither valid Decree No 82/1999 Coll. nor the amendment include such environmental objectives at present. and Podle čl. 16 (7) Směrnice 2000/60/ES Evropského parlamentu a Rady ustavující rámec pro činnost Společenství v oblasti vodní politiky má Komise předložit Evropskému parlamentu a Radě návrhy environmentálních standardů pro koncentrace prioritních látek v povrchových vodách, sedimentech a v biotě. V případě absence úmluvy na úrovni Společenství do termínu daného směrnicí musejí členské státy stanovit tyto environmentální standardy samy. V rámci legislativní přípravy na takovou eventualitu jsme proto hodnotili vztahy mezi jednotlivými parametry kontaminace vody a plavenin těžkými kovy a arsenem jako jednou skupinou prioritních látek. Platné Nař. vl. ČR č. 82/1999 Sb. ani připravovaná novela zatím environmentální standardy pro sedimenty (a tedy ani plaveniny) a biotu nezahrnují.
Chronic allograft nephropathy (CAN) represents a frequent and irreversible cause of long-term renal graft loss. TGF- β 1 is a key profibrogenic cytokine associated with CAN pathogenesis. Because of clinical diagnostic inaccuracy, protocol biopsy has been suggested to be a beneficial method for early CAN detection. Protocol core biopsy was carried out in 67 consecutive cyclosporine-based immunosuppression-treated kidney transplant recipients with stable renal function 12 months after renal transplantation. Biopsy specimens were analyzed morphologically according to Banff-97' criteria and immunohistologically for TGF- β 1 staining. The data obtained were correlated with plasma TGF- β 1 levels and clinical data. CAN (grade I-III) was found in 51 patients (76 %). CAN grade I was found to be the most frequent one (44 %). A normal finding within the graft was made in only 12 patients (18 %). Clinically silent acute rejection Banff IA was present in 4 patients (6 %). In 8 patients (12 %) with CAN, borderline changes were present. We found a significant correlation between CAN grade and creatinine clearance, as measured by the Cockroft-Gault formula (p<0.01) as well as body mass index (p<0.01). There was a significant correlation between chronic vasculopathy (Banff cv) and creatinine clearance, and between the degree of TGF- β 1 staining and chronic vasculopathy (p<0.01). There were no relations between morphological findings and TGF- β 1 plasma levels, cyclosporine levels, plasma lipids, HLA- mismatches, panel reactive antibodies (PRA), proteinuria, and the donor's age. In conclusion, CAN is a frequent finding in protocol kidney graft biopsies 12 months after transplantation. TGF- β 1 tissue expression is linked with chronic vasculopathy., O. Viklický, I. Matl, L. Voska, R. Böhmová, M. Jarešová, J. Lácha, A. Lodererová, I. Stříž, V. Teplan, Š. Vítko., and Obsahuje bibliografii
The aim of this article is to sketch a certain method of indirect reconstruction of the process by which mathematics as a deductive discipline emerged in ancient Greece. We try out this method in a reconstruction of Thales' mathematics, but the main aim for which this method has been developed is the work of Pythagoras. We consider the process of the emergence of mathematics as a process of the constitution of a new language in the framework of which one can carry out deductive proofs. Therefore we base the method of indirect reconstruction of the emergence of mathematics on the theoretical findings in the book L. Kvasz: Vedecká revolúcia ako lingvistická událosť (The Scientific Revolution as a linguistic event, Prague, Filosofia 2013)., Ladislav Kvasz., and Obsahuje poznámky a bibliografii