This research is a follow-up to the previous research which was dealing with the creation of the simulation of the vocal cords function using FEM. This paper focuses on how the vocal cords function is affected by Bernoulli's effect, while using model [1] is used. It is well known, that Bernoulli's effect is connected with the suction in the air space between the vocal cords. This is caused by the high air flow in glottis. The fastest and easiest way how to eliminate the influence of this effect is the change of every negative air pressure on the vocal cords to zero (i.e. the pressure applied as the loads on the vocal cords). Authors of some vocal cords models presume that Bernoulli's effect is the main force causing vocal cords vibrations. Changing the negative pressures to zero should cause that the vocal cords would not vibrate. However, the results of this research show the opposite. and Obsahuje seznam literatury
In order to utilize the absolute gravity ( AG) measurements in terms of tectonic study it is necessary to reduce all disturbing environmental and instrumental effects. Many of those can be easily modelled and this step is done routinely during measurements (i.e. tide, polar motion, ocean tidal loading). Other remains in data and there is a lack of conventional models for them. Significant gravity variation is associated with changes of soil water at global scale. We study this effect for the Lower Silesia (South-western Poland) territory. Computed gravity changes can reach up to 2 μgal peak-to-peak amplitude with seasonal time scale. This effect is beyond of accuracy of modern ballistic gravimeter. Using real data collected with FG5 gravimeter we show here that neglecting of this phenomenon can lead to serious misinterpretation in term of secular gravity changes. This is emphasized especially when only sparse data of a few year time span is at our disposal. No attempt of modelling of local hydrology impact on effect was made, while in this study we concentrate on large scale water storage influence on measured gravity., Marcin Rajner, Tomasz Olszak, Jerzy Rogowski and Janusz Walo., and Obsahuje bibliografické odkazy
Test stand for investigation of the influence of bearing bushing movement control on behaviour of a rigid rotor supported in sliding journal bearings was designed. The stand was equipped with two pairs of piezoactuators, enabling to move each bearing bushing in two directions, and with two pairs of relative sensors tracing shaft movement at both bearings. The initial tests showed quite unexpected phenomena, which should be cleared up, before experiments with controlled bearing bushing movement could be started. Finally the system began to operate according to predictions and it was possible to start intended experiments. Some results of the rotor behaviour with and without piezoactuator action are presented.
One of the basic questions related to the safety of dikes and river levees is the size of the freeboard. One of the important parameters for freeboard design is the height of waves and wave run-up on levee slopes. Routine and standardised calculations of wave run-up deal with the freeboards of dams where wind waves originate on the still water of the reservoir. In the case of running water in streams (thereinafter only ''currents'') the effect of wave and current interaction on wave run-up is usually not taken into account due to the lack of reliable knowledge regarding the phenomenon. In the Czech Republic this question is topical in the case of large rivers such as the Elbe, the Vltava and the Morava. Within the framework of the projects Hydralab III and NAZV QI 92A139, hydraulic research and further analysis focused on wave run-up as a result of the combination of current and wind wave parameters were performed. The laboratory research was carried out in a hydraulic flume with a wavemaker on the right bank and a levee with a slope of 1:3 installed on the left bank opposite the wavemaker. Waves were generated both perpendicular and oblique to the levee axis; the angle of oblique wave attack varied within the range of ± 30°. The aim of this paper is to compare the results of the mentioned research with recommendations mentioned in the Czech National Standard CSN 75 0255 Calculation of wave effects on water structures and to quantify the effect of current on the wave run-up height. and Jednou ze základních otázek spojených s bezpečností hráze je návrh převýšení její koruny nad maximální hladinou vzdouvané vody. Důležitým parametrem ovlivňujícím návrh převýšení je výška vln vybíhajících po svahu hráze. Běžné postupy výpočtu výšky výběhu vlny na svah jsou realizovány za předpokladu, že vlny vznikají na stojatých vodách. Vliv proudění se obvykle vzhledem k nízké úrovni znalostí tohoto jevu na tekoucích vodách zanedbává. V podmínkách České Republiky je otázka vlivu proudění na výšku výběhu relevantní zejména na velkých tocích jako Labe, Vltava nebo Morava. V rámci projektů Hydralab III a NAZV QI 92A139 byl uskutečněn hydraulický výzkum a analýza dat se speciálním zaměřením na výšku výběhu větrových vln při započtení vlivu proudění. Výzkum byl realizován na modelu hráze se sklonem svahu 1 : 3, který byl umístěn ve zkušební nádrži osazené vlnoproduktorem vedeným rovnoběžně s modelem hráze. Vlny zde byly generovány jednak kolmo vzhledem k podélné ose hráze, jednak šikmo v rozsahu úhlů ± 30°. Výsledky výzkumu byly porovnány s doporučeními uvedenými v České státní normě ČSN 75 0255 Výpočet účinků vln na stavby na vodních nádržích a zdržích.
Calorie restriction (CR) has been shown to decrease reactive oxygen species (ROS) production an d retard aging in a variety of species. It has been proposed that alterations in membrane saturation are central to these ac tions of CR. As a step towards testing this theory, mice were assigned to 4 dietary groups (control and 3 CR groups) and fed AIN-93G diets at 95 % (control) or 60 % (CR) of ad libitum for 8 months. To manipulate membrane composition, the primary dietary fats for the CR groups were soybean oil (also used in the control diet), fish oil or lard. Skeletal muscle mitochondrial lipid composition, proton leak, and H 2 O 2 production were measured. Phospholipid fatty acid composition in CR mice was altered in a manner that reflected the n-3 and n-6 fatty acid profiles of their respective dietary lipid sources. Dietary lipid composition did not alter proton leak kinetics between the CR groups . However, the capacity of mitochondrial complex III to produce ROS was decreased in the CR lard compared to the other CR groups. The results of this study indicate that dietary lipid composition can influence ROS production in muscle mitochondria of CR mice. It remains to be determined if lard or other dietary oils can maximize the CR- induced decreases in ROS production., Y. Chen ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy
Influence of the pattern of effective rainfall on modeled hydrograph was investigated in the study. The modelling was performed with the U.S. Army Corps of Engineers hydrograph package HEC-HMS 3.2 and calibrated and validated on measured hydrographs of Glinscica watershed. Six different models of rainfall loss were applied and their effect on modeled hydrograph was evaluated. Peak discharge, time of peak discharge and runoff volume were compared. The best results with the lowest RMSE in the study was obtained with the SCS curve number loss method. Also synthetic hyetographs of different probability and duration were used. Three positions of the maximum rainfall intensity at 25, 50 and 75 % of the rainfall duration were applied. The results showed essential differences in simulated time to peak and also differences in peak discharge. The differences in time to peak increases considerably with the increasing of the rainfall duration. Finally, the results of constant intensity distribution of rainfall of different durations were compared with those obtained with typical rainfall distribution with the position of the maximum intensity at 50 %. Results showed considerable differences in peak discharge and time to peak by longer durations of the rainfall. and Práca obsahuje výsledky výskumu vplyvu efektívnych zrážok na modelovaný hydrograf. Odtok bol modelovaný pomocou nástroja U.S. Army Corps of Engineers hydrograph package HEC-HMS 3.2, potom kalibrovaný a verifikovaný na meraných hydrografoch povodia Glinscica. Vplyv zrážok na modelovaný hydrograf bol vypočítaný pre šesť rôznych modelov priebehu zrážok. Porovnali sme maximálne prietoky, časy ich trvania a odtečené množstvá. Najlepšie výsledky s najnižším RMSE sme získali s SCS modelom odtoku. Použili sme tiež syntetické hyetografy rozdielnej pravdepodobnosti a trvania. Použili sa tri polohy maximálnych intenzít zrážok; pre 25, 50 a 75 % ich trvania. Výsledky ukázali zásadný rozdiel v simulovaných časoch maximálneho prietoku a tiež rozdiely v maximálnych prietokoch. Rozdiely v časoch dosiahnutia maximálnych odtokov sa výrazne zvyšovali s časom trvania zrážky. Nakoniec sme porovnali výsledky výpočtov s konštantnými intenzitami rozdelenia s rôznym trvaním zrážky s tými, ktoré boli vypočítané s použitím typických rozdelení, s polohou maximálnej intenzity zrážok pri 50 % ich trvania. Výsledky ukazujú významné rozdiely v maximálnych prietokoch a v časoch ich dosiahnutia v závislosti od trvania zrážky.
Gamma irradiation with a dose of 5.7 Gy within 30 min before partial hepatectomy (PHE) caused latent damage in the intact rat liver. This was expressed in the course of proliferation induced in the liver remnant by inhibition of the regenerative process, which was indicated by a decreased mitotic index and cellularity, an increased ratio of metaphases/prophases and a high chromosomal aberration frequency. The preparation of essential phospholipids (ESSENTIALE) that was injected in a dose of 360 mg/kg (i.p.) either 24 h before irradiation or 30 min after irradiation or repeatedly before and after irradiation, markedly stimulated the process of liver regeneration after PHE in both nonirradiated and irradiated rats. It moderated all the alterations induced by irradiation, especially changes in cellularity. The most effective was the repeated administration of ESSENTIALE whereas its single administration before irradiation was more effective than that after irradiation. Our results suggest that ESSENTIALE has not only a stabilizing effect on cell membranes, but also mitigates damage of genetic material induced by irradiation.
The aim of this study was to observe the effect of folate and antioxidants alone on homocysteine levels and oxidative stress markers, and to evaluate whether their co-administration promotes their effects. One hundred patients with hyperhomocysteinemia were randomized into four equal groups, which were then treated with folate, antioxidants or
folate plus antioxidants for 2 months; group IV was a control group. Serum homocysteine, folate and oxidative stress markers were measured before the study, at the end of folate and/or antioxidants administration and 3 months later. Folate caused a significant decrease in homocysteine concentration. Antioxidants did not influence homocysteine concentration, but they improved the antioxidative defense (plasma antioxidant capacity and intraerythrocyte
glutathione were increased) and partially prevented lipid peroxidation (malondialdehyde level was slightly decreased). Supplementation with folate had a similar effect on intracellular glutathione and plasma malondialdehyde. Simultaneous administration of folate and antioxidants did not show any additive effect with the exception of a slower decrease of folate concentration after its supplementation had been discontinued. Folate may be considered as an effective antioxidant in patients with hyperhomocysteinemia; this can be a result of decreased production of free radicals due to a reduced level of homocysteine. Its antioxidative effect cannot be promoted by co-administration of antioxidants.
The haemolytic action of HgCl2 (0, 15 mmol.l'1) was studied in relation to the ionic strength and concentration of glucose and saccharose in incubating medium. Blood from 94 donors, aged 19-46 years were used in our experiments. In relation to the ionic strength the haemolytic action was characteristic with two maxima of haemolysis. The first at low ionic strength and second one at the high. Both maxima in solutions containing saccharose were significantly diminished in glucose. These facts show a negative influence of saccharose on the haemorheological properties of the erythrocyte membrane.
Adiponectin is an adipocyte-derived hormone involved in the regulation of carbohydrate and lipid metabolism. Its concentrations are decreased in patients with obesity, type 2 diabetes and atherosclerosis and are higher in females than in males. Gender differences of adiponectin levels raise the possibility that sex hormones directly regulate its serum concentrations, which may in turn influence insulin sensitivity in different phases of the menstrual cycle. To test this hypothesis we measured serum adiponectin, estradiol, progesterone, luteinizing hormone and follicle-stimulating hormone concentrations daily throughout the menstrual cycle in six healthy women. Mean adiponectin levels strongly positively correlated with serum cortisol concentrations [R=0.94286; p=0.0048 (Spearman correlation test)], but were not significantly related to other anthropometric, biochemical and hormonal characteristics of the subjects (BMI, blood
glucose, insulin, testosterone, prolactin, cholesterol, HDL cholesterol, LDL cholesterol, triglycerides concentrations, or atherogenic index). Furthermore, no significant changes of serum adiponectin levels were found throughout the menstrual cycle. We conclude that changes in sex hormones during the menstrual cycle do not affect total circulating
adiponectin levels in healthy women. Therefore, the differences in insulin sensitivity in various phases of the menstrual cycle are not due to changes of circulating adiponectin levels.