In the rat model, 6-hydroxydopamine (6-OHDA) known as a selective catecholaminergic neurotoxin used chiefly in modeling Parkinson's disease (PD). Continuous aerobic exercise and curcumin supplementations could play a vital role in neuroprotection. This study aimed to explore the neuroprotective roles of regular aerobic exercise and curcumin during PD. For this, rats were treated as follows for 8 consecutive weeks (5 d in a week): For this, animals were orally treated with curcumin (50 ml/kg) alone or in combination with aerobic exercise. Compared with a control group, induction of PD by 6-OHDA increased the amount of α-synuclein protein and malondialdehyde levels and decreased the number of substantia nigra neurons, total antioxidant capacity, and glutathione peroxidase activity in brain tissue. All these changes were abolished by the administration of curcumin with aerobic exercise treatments. Activity behavioral tests also confirmed the above-mentioned results by increasing the rod test time and the number of rotations due to apomorphine injection. Histopathology assays mimic the antioxidant activity and behavioral observations. Combined curcumin with aerobic exercise treatments is potentially an effective strategy for modifying the dopaminergic neuron dysfunction in 6-OHDA-induced rats modeling PD via dual inhibiting oxidative stress indices and regulating behavioral tasks.
In 1955, the work started in the Institute for Theoretical Radio Engineering of the Czechoslovak Academy of Sciences, the predecessor of today’s Institute of Photonics and Electronics of the Czech Academy of Sciences. In the year 2015, proclaimed as the International Year of Light by the UNESCO, let us recall selection of the milestones of the past 60 years of scientific research in our institution, particularly those related to photonics and light. and V roce 1955 zahájil svou činnost Ústav teoretické radiotechniky Československé akademie věd, předchůdce dnešního Ústavu fotoniky a elektroniky Akademie věd České republiky. V roce 2015, vyhlášeným UNESCO za Mezinárodní rok světla, si připomeňme výběr z některých milníků už 60 leté historie vědeckého bádání v našem ústavu, zejména těch se vztahem k fotonice a světlu.