6-Hydroxydopamine-induced neurotoxicity in rat model of Parkinson’s disease: is reversed via anti-oxidative activities of curcumin and aerobic exercise therapy

Title:

6-Hydroxydopamine-induced neurotoxicity in rat model of Parkinson’s disease: is reversed via anti-oxidative activities of curcumin and aerobic exercise therapy

Creator:

Sokouti, Hadis, Mohajeri, Daryoush, and Nourazar, Mir Alireza

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:16eefee2-c751-4c3d-a165-21ef09ce2801
uuid:16eefee2-c751-4c3d-a165-21ef09ce2801
doi:10.33549/physiolres.934929

Subject:

6-OHDA, Parkinson's disease, aerobic exercise, curcumin, behavioral tasks, and oxidative stress

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

In the rat model, 6-hydroxydopamine (6-OHDA) known as a selective catecholaminergic neurotoxin used chiefly in modeling Parkinson's disease (PD). Continuous aerobic exercise and curcumin supplementations could play a vital role in neuroprotection. This study aimed to explore the neuroprotective roles of regular aerobic exercise and curcumin during PD. For this, rats were treated as follows for 8 consecutive weeks (5 d in a week): For this, animals were orally treated with curcumin (50 ml/kg) alone or in combination with aerobic exercise. Compared with a control group, induction of PD by 6-OHDA increased the amount of α-synuclein protein and malondialdehyde levels and decreased the number of substantia nigra neurons, total antioxidant capacity, and glutathione peroxidase activity in brain tissue. All these changes were abolished by the administration of curcumin with aerobic exercise treatments. Activity behavioral tests also confirmed the above-mentioned results by increasing the rod test time and the number of rotations due to apomorphine injection. Histopathology assays mimic the antioxidant activity and behavioral observations. Combined curcumin with aerobic exercise treatments is potentially an effective strategy for modifying the dopaminergic neuron dysfunction in 6-OHDA-induced rats modeling PD via dual inhibiting oxidative stress indices and regulating behavioral tasks.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

551-560

Source:

Physiological research | 2022 Volume:71 | Number:4

Harvested from:

CDK

Metadata only:

false