Studie Tomáše Hlobila se zabývá náplní přednášek estetika Johanna Heinricha Dambecka, které Dambeck přednášel během svého pedagogického působení na pražské univerzitě., This article examines contemporaneous reports about two versions of lectures in aesthetics, which were given at Prague University by Johann Heinrich Dambeck (1774–1820). They were recorded by the publisher Joseph Adolf Hanslik (1785–1859) in a manuscript summary in 1819 and a two-volume book published in 1822 and 1823. The article presents a comparison of the two sources in order to determine which parts of the commentary originate with Dambeck and which with Hanslik. Considering the large scope and the bibliographical nature of the chief part of the appendices to the book, the author of the article concludes that they originated not with Dambeck, but with Hanslik., Tomáš Hlobil., Rubrika: Studie, and Německé resumé na s. 130, anglický abstrakt na s. 123.
a1_A new concept of cardioprotection based on the exploitation of endogenous mechanisms is known as ischemic preconditioning (IPC). It has been hypothesized that substances released during brief ischemic stress (e.g. catecholamines) stimulate the receptors and trigger multiple cell signaling cascades. Opening of ATP-sensitive K+ channels [K(ATP)] has been suggested as a possible final step in the mechanisms of protection. In this study, the role of adrenergic activation was tested in Langendorff-perfused rat hearts subjected to test ischemia (TI; 30 min occlusion of LAD coronary artery) by: 1) mimicking IPC (5 min ischemia, 10 min reperfusion) with short-term (5 min) administration of norepinephrine (NE, 1 µM), 15 min prior to TI; 2) blockade with b- or a1-receptor antagonists, propranolol (10 µM) and prazosin (2 µM), respectively, applied 15 min prior to TI during IPC. The role of K(ATP) opening was examined by perfusion with a K(ATP) blocker glibenclamide (10 mM) during IPC. Both IPC and NE-induced PC effectively reduced the incidence of ventricular tachycardia (VT) to 33 % and 37 %, respectively, vs 100 % in the non-PC controls, whereby ventricular fibrillation (VF) was totally abolished by IPC and markedly suppressed by PC with NE (0 % and 10 %, respectively, vs 70 % in the non-PC hearts; P<0.05). The severity of arrhythmias (arrhythmia score, AS) was also markedly attenuated by both interventions (IPC: AS 1.7±0.4; NE-PC: AS 1.8±0.3 vs AS 4.1±0.2 in the controls; P<0.05). Protection was not suppressed by propranolol (VT 28 %; VF 14 %; AS 2.2±0.6), whereas prazosin reversed the protective effect of PC (VT 83 %; VF 67 %; AS 4.0±0.8). Antiarrhythmic protection afforded by NE-PC was abolished by pretreatment of rats with pertussis toxin (25 mg/kg, i.p.) given 48 h prior to the experiments., a2_Glibenclamide did not suppress the IPC-induced protection. In conclusion, the sensitivity of the rat heart to ischemic arrhythmias can be modulated by IPC. Protection is mediated via stimulation of a1-adrenergic receptors coupled with Gi-proteins but glibenclamide-sensitive K(ATP) channels do not appear to be involved in the mechanisms of antiarrhythmic protection in this model., T. Ravingerová, D. Pancza, A. Ziegelhoffer, J. Styk., and Obsahuje bibliografii
Na příkladech 5ti respondentů a jejich rodinných příslušníků jsme analyzovali průběh léčby, rehabilitace, péče v komunitě lidí po poranění mozku a náklady s tím spojené. Neméně důležitým cílem případové studie bylo zhodnocení vlivu poranění mozku na život respondentů a jejich rodin. Výsledky ukazují, že průběh zdravotní péče a s tím spojených nákladů zdravotní péče byl u většiny sledovaných přípa, autoři Tomáš Roubal ... [et al.] ; editor Tereza Žílová, and Obsahuje literaturu
The paper reflects a long-term ambiguity in the theoretical concept of affective phenomena. The focal point of this study is the conceptualization of the term “affect” with regard to the other affective phenomena (specifically emotion and mood). Our definition of affect is substantially different than existing Czech terminology and we define affect as the necessary component of all affective processes. Contrary to the Czech traditional concept of affect, we do not attribute characteristics such as “high intensity” or “disorganising influence” on cognitive processes, behaviour, etc. per se. We define affect in accordance with many authors, as a point in the continuum of affective stream and the basic unit of all affective phenomena. Affective phenomena or processes we consider as an umbrella term for a complex phenomenon like affect, emotion, mood, emotional episode, interpersonal attitude, sentiment, passion and so on: their common component is the affect. We consider emotion as a figure that emerges in the affective stream as a complex reaction to the event that has meaning for an individual and is interpreted with respect to the experience, context, individual characteristic, and sociocultural environment of the individual. Contrary to the Czech tradition, emotions are viewed as “just” one type of affective phenomena with a relatively specific definitional framework. The moods are considered parts of the affective stream continuum that have a specific and for consciousness accessible quality. The concepts of affect, emotion and mood discussed in this paper are contrasted; however, we have described where they overlap conceptually. The relationships of all affective phenomena have been considered as interacting with a tendency to synchronize into one (for an individual typical) affective stream., I. Poláčková Šolcová, R. Trnka., and Obsahuje seznam literatury
Studie Karla Veverky se zabývá mešními díly hudebního skladatele Antonia Caldary, jejichž opisy se dochovaly v hudebních sbírkách v Praze, se zaměřením na významnou sbérku hudebnin z kůru pražských křižovníků., This study deals with individual aspects and problems of research on the Masses by Antonio Caldara with source materials held in Prague. Representing the basic material are two copies from the collection of the Knights of the Cross with the Red Star along with concordant sources amassed from Czech and foreign archives. The effectiveness of the standard methods used for studying musical sources is put to the test on a selected sampling of material. The comparison of individual copies helps answer questions not only about provenience or filial relationships between materials, but also about period performance practice. The goal of the study is to make at least a partial contribution towards systematic research on the musical life of Prague in the first half of the 18th century, when Caldara’s Masses were significantly represented in church music collections., Karel Veverka., Rubrika: Studie, and Anglické resumé na s. 93, anglický abstrakt 81.
a1_Cíle. Propoziční hustota (PH), psycholingvistické měřítko, koreluje s kognitivní kapacitou ve starším věku. Tato studie zjišťuje rozdíly v propoziční hustotě v orálních výpovědích na téma z nedávné minulosti u osob zdravých a s mírnou kognitivní poruchou (MKP). MKP je v současnosti přijímána jako prodromální stádium Alzheimerovy nemoci (AN). Soubor. Soubor zahrnoval 33 osob s MKP a 32 zdravých kontrol (průměrný věk 73 let). Obě skupiny byly vyrovnané, a to co do věku a úrovně dosaženého vzdělání. Dle očekávání se lišily v skóru MMSE, který je považován za zjednodušené vyjádření úrovně kognitivního stavu. Hypotézy. Nižší PH byla očekávána u osob s MKP, neboť úkol zatěžoval vybavení z novopaměti. Přičemž obtíž se zapamatováním nových informací, a tedy i vybavením z novopaměti, je jedním z jádrových symptomů AN., a2_Analýza a výsledky. Průměrná propoziční hustota u pacientů s MKP činila 48,74 % (sm. odch. 5,78), u kontrolního vzorku seniorů bez kognitivních poruch to bylo 53,06 % (sm. odch. 4,56). Studentův t-test prokázal statisticky významný rozdíl mezi skupinami (p < 0,001). Cohenovo d 0,83 reprezentuje velký efekt příslušnosti ke skupině. Omezení. Nejpodstatnějším omezením této studie je heterogenita diagnostické jednotky MKP. Dalším omezením byla neznalost premorbidní kognitivní úrovně zdravých kontrol, proto je možné, že v kontrolní skupině byly osoby s již počínající kognitivní poruchou, jež byla při jednorázovém vyšetření nezachytitelná., b1_Objectives. It has been shown that propositional density (PD), which roughly corresponds to the number of ideas expressed in a text of given length, is related to cognitive performance in the older age. The present study investigated differences in propositional density in oral language production between healthy seniors and patients with mild cognitive impairment (MCI). MCI is generally accepted as a prodromal stage of Alzheimer’s disease (AD). Sample and setting. The sample included 33 MCI persons and 32 healthy controls (mean age 73 years). The groups were equivalent as for the age and education. As expected, there was a significant difference between Mini-Mental State Examination (MMSE) scores between the groups, with MMSE being a simplified measure of their cognitive status. Hypotheses. Lower PD was expected in MCI persons, as the task required recent past recall which is considered one of the early deficiencies in early AD and MCI due to AD., b2_Statistical analysis. Mean PD across groups was compared using the independent samples t-test. Results. Mean propositional density in MCI persons was 48,74% (SD 5,78), and in healthy controls 53,06% (SD 4,56). The difference was statistically significant (p<0,001). Cohen’s d 0,83 represents a large effect size for the group difference. Study limitations. The main limitation is the heterogeneity of the MCI group. Also, the detailed cognitive status of the healthy controls is unknown. Thus the group could include persons with some cognitive impairment which has not been detected yet., Hana Štěpánková, Filip Smolík, Martin Vyhnálek, Tomáš Nikolai, Karolína Horáková, Markéta Niederlová., and Obsahuje seznam literatury