Drawing on literary paratexts such as prologues, reviews and letters, this study seeks answers to the question of Meissner’s role in the German-language canon, or rather why his literary legacy has endured for so long. First, Meissner’s personal contacts in the world of literature from a social-historical perspective is considered. This reveals that the repeated criticism of Meissner’s texts, which despite their popularity were to a large extent at odds with the taste of the time, cast him in a bad light. Selected relevant texts will be placed in their discursive context and Meissner’s writings within the parameters of 18th century literary practice examined., Sarah Seidel., and Obsahuje bibliografické odkazy
Neurohumoral substances and their receptors play a major part in the complex regulation of gastrointestinal motility and have therefore been the predominant targets for drug development. The numerous receptors involved in motility are located mainly on smooth muscle cells and neuronal structures in the extrinsic and intrinsic parts of the enteric nervous system. Within this system, receptor agonists and antagonists interacts directly to modify excitatory or inhibitory signals. In view of this complexity it is not surprising that our knowledge about the mechanisms of actions of the various neurohormones and drugs affecting gut motility has been rather fragmented and incomplete. However, recently substantial progress has been achieved, and drug therapy for gut dysmotility is emerging, based primarily on neurohumoral receptors. This paper presents a selective review of the neurohumoral regulatory mechanisms of gastrointestinal motility. In this context, the physiology and pharmacology of the smooth muscle cells, gastrointestinal motility and dysmotility, the enteric nervous system, gastrointestinal reflexes, and serotonin is presented. Further investigation and understanding of the transmitters and receptors involved in especially the reflex activation of peristalsis is crucial for the development of novel therapies for motility disorders., M. B. Hansen., and Obsahuje bibliografii