In this paper, the boundedness of a large class of sublinear commutator operators $T_{b}$ generated by a Calderón-Zygmund type operator on a generalized weighted Morrey spaces $M_{p,\varphi }(w)$ with the weight function $w$ belonging to Muckenhoupt's class $A_{p}$ is studied. When $1<p<\infty $ and $b \in {\rm BMO}$, sufficient conditions on the pair $(\varphi _1,\varphi _2)$ which ensure the boundedness of the operator $T_{b}$ from $M_{p,\varphi _1}(w)$ to $M_{p,\varphi _2}(w)$ are found. In all cases the conditions for the boundedness of $T_{b}$ are given in terms of Zygmund-type integral inequalities on $(\varphi _1,\varphi _2)$, which do not require any assumption on monotonicity of $\varphi _1(x,r)$, $\varphi _2(x,r)$ in $r$. Then these results are applied to several particular operators such as the pseudo-differential operators, Littlewood-Paley operator, Marcinkiewicz operator and Bochner-Riesz operator.