Induced pluripotent stem cells (iPSC) are undifferentiated cells capable of unlimited self-renewal. By introducing specific transcription factors, any somatic (fully differentiated) cell of the mammalian body can be changed (reprogrammed) into iPSC. The iPSCs are very similar to embryonic stem cells in their molecular and functional properties. By using specific factors, iPSCs can be differentiated into each of the about 200 cell types in the human body. The big advantage of iPSCs is the availability of somatic cells (isolation from blood or skin biopsy). Creation of "tailor made" iPSCs for each patient would allow transplantation of own cells and avoid problems with finding an immunologically compatible donor. and Kateřina Vodičková Kepková, Petr Vodička, Jan Motlík.