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Start Over Subject Dehydroepiandrosterone

1. 7 - Hydroxydehydroepiandrosterone - a Natural Antiglucocorticoid and a Candidate for Steroid Replacement Therapy?

Creator:
Hampl, R., Lapčík, O., Hill, M., Klak, J. , Kasal, A., Nováček, A. , Šterzl, I., Šterzl, J., and Stárka, L.
Type:
article, model:article, and TEXT
Subject:
Dehydroepiandrosterone, 7-Hydroxydehydroepiandrosterone, Antiglucocorticoid, Immunoprotection, and Hormone replacement
Language:
English
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

2. Decrease in serum dehydroepiandrosterone level after fenofibrate treatment in males with hyperlipidemia

Creator:
Šulcová, J., Štulc, T., Hill, M., Hampl, R., Mašek, Z., Vondra, K., and Češka, R.
Type:
article, model:article, and TEXT
Subject:
Dehydroepiandrosterone, Estradiol, Fenofibrate, hyperlipidemia, and SHBG
Language:
English
Description:
The influence of steroid hormones on plasma lipids and lipoproteins was confirmed by many studies. On the other hand, the effect of plasma lipids on metabolism of steroid hormones has so far not been examined. The objective of this research project was to determine (1) the levels of cortisol, testosterone, estradiol, dehydroepiandrosterone (DHEA), its sulfate (DHEAS), 7-hydroxylated DHEA, and SHBG in men suffering from mixed hyperlipidemia (HPL) (n=23, age 46.1±7.9 years) in comparison with healthy male volunteers (n=17, age 45.1±15.6 years); (2) whether therapy with fenofibrate influences the levels of the above mentioned steroids and SHBG; (3) what are the correlations between lipids and steroids in healthy males and HPL patients before and after therapy. Compared to controls, untreated patients had significantly higher estradiol and free testosterone index (IFT) levels (p<0.0003 and p<0.02, respectively) and significantly lower SHBG (p<0.02). Due to fenofibrate therapy, a significant decrease of TC, TG, and DHEA levels occurred (mean decrease: 14 %, 52 % and 21 %, respectively). Triglycerides correlated negatively with testosterone and SHBG in healthy subjects. HDL-C correlated positively and consequently, atherogenic index correlated negatively with 7-hydroxylated epimers of DHEAin treated patients. This is the first study dealing with the influence of fenofibrate administration on the steroid levels. Taking together, the most important is the finding of decrease DHEA levels after fenofibrate therapy. It could be explained, at least in part, by the effect of the fenofibrateon on the biosynthesis of DHEA and its regulation.
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public