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2. Electrocardiographic dose-dependent changes in prophylactic doses of dosulepine, lithium and citalopram

Creator:
Ivo Paclt, Jaroslav Slavíček, Alena Dohnalová, Eva Kitzlerová, and Klára Semerádová
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, lithium, ECG, body surface potential maps, dosulepine, citalopram, dose-dependent changes, prophylactic doses, 14, and 612
Language:
English
Description:
Tricyclic antidepressant drugs dosulepine (TCA), serotonin selective reuptake inhibitor (SSRI) and prophylactic agent with antidepressant effect lithium carbonicum (Li) have different cardiovascular side-effects. We compared them in the prophylactic therapy of periodic affective disorder in remission with TCA, SSRI and Li. Our previous papers confirmed the most prominent effects of heart electric field parameters in TCA patients (Slavíček et al. 1998). In the present work we studied for the first time the dose-dependent changes of ECG, body surface potential maps (BSPM - parameter DIAM 30, 40) in 43 TCA dosulepine, 40 SSRI citalopram and 30 Li outpatients (Hamilton scale: HAMD£10; age 40±5 years; treated for depressive disorders or bipolar disorders). The daily doses of dosulepine were 50-250 mg, citalopram 20-80 mg, Li plasma levels 0.66±0.08 meq/l. The electrocardiogram (ECG), vectorcardiogram (VCG), and BSPM were measured and calculated by the Cardiag 112.1 diagnostic system. The results have shown a relation between the dose of dosulepine and extremum (maximum and minimum) of depolarization isoarea map in dosulepine, but not in citalopram patients. The repolarization BSPM changes were most pronounced in SSRI patients. Lithium in long-term prophylaxy (1-22 years) caused only minimal ECG BSPM changes. The present results correspond with our previous observations., I. Paclt, J. Slavíček, A. Dohnalová, E. Kitzlerová, K. Pišvejcová., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

3. Repolarization pattern of body surface potential maps (BSPM) in coronary artery disease

Creator:
Kittnar, O., Slavíček, J., Vávrová, M., Barna, M., Dohnalová, A., Málková, A., Aschermann, M., Humhal, J., Hradec, J., and Král, J.
Type:
article, model:article, and TEXT
Subject:
body surface potential maps, coronary artery disease, repolarization, and cardiac wall kinetics
Language:
English
Description:
The aim of our study was to assess if repolarization BSPM were able to evaluate the site, size and severity of chronic ischaemic damages and if BSPM were in any way related to the regional attenuation of myocardial contractility or to the site of coronary artery occlusion. The BSPM were obtained from 69 patients suffering from coronary artery disease confirmed by coronarography, with at least 75 % occlusion of at least one coronary artery. According to the site of single occlusion, or a combination of the sites of multiple occlusions, the patients were divided into 6 subgroups. According to the region of attenuated kinetics the same group of 69 patients was also divided into other 6 subgroups. As in the polarity distribution there was only a limited accordance in BSPM with coronarographie and échocardiographie Findings, in the localization of extreme values there were very important specific changes in patients with normal kinetics as determined by both contrast ventriculography and two-dimensional echocardiography. The repolarization maps can distinguish patients with coronary artery disease and normal echocardiography from healthy persons with a sensitivity of 85 % and a specificity of 65 % in the case of the isoareal map from the ST segment (R1AM) and 90 % and 85 %, respectively, in the case of the isointegral map from the whole ST-T segments (R1IM).
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public