Different sensitivity of miniature endplate currents in rat external and internal intercostal muscles to the acetylcholinesterase inhibitor C-547 as compared with diaphragm and extensor digitorum longus

Title:

Different sensitivity of miniature endplate currents in rat external and internal intercostal muscles to the acetylcholinesterase inhibitor C-547 as compared with diaphragm and extensor digitorum longus

Creator:

Petrov, K., Kovyazina, I., Zobov, V., Bukharaeva, E., Nikolsky, E. E., and František Vyskočil

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:011e1255-b6e2-4c99-b50e-5ac10fda5243
uuid:011e1255-b6e2-4c99-b50e-5ac10fda5243

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, kosterní svaly, acetylcholin, physiology, striated muscles, acetylcholine, miniature endplate current, acetylcholinesterase, anticholinesterase, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Derivative of 6-methyluracil, selective cholinesterase inhibitor C-547 potentiates miniature endplate currents (MEPCs) in rat external intercostal muscles (external ICM) more effectively than in internal intercostal muscles (internal ICM). Effect of the C-547 on intercostal muscles was compared with those on extensor digitorum longus (EDL) and diaphragm muscles. Half-effective concentrations for τ of MEPC decay arranged in increasing order were as follows: EDL, locomotor muscle, most sensitive = 1.3 nM, external ICM, inspiration muscle = 6.8 nM, diaphragm, main inspiration muscle = 28 nM, internal ICM, expiration muscle = 71 nM. External ICM might therefore be inhibited, similarly as the limb muscles, by nanomolar concentrations of the drug and do not participate in inspiration in the presence of the C-547. Moreover, internal ICM inhibition can hinder the expiration during exercise-induced fast breathing of C-547-treated experimental animals., K. Petrov ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2009 Volume:58 | Number:1

Harvested from:

CDK

Metadata only:

false