Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat?

Title:

Does exogenous melatonin influence the free radicals metabolism and pain sensation in rat?

Creator:

Pekárková, I., Parara, S., Václav Holeček, Stopka, P., Ladislav Trefil, Jaroslav Racek, and Richard Rokyta

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:022a4cab-3dcb-4561-8ccd-fd4ab9842900
uuid:022a4cab-3dcb-4561-8ccd-fd4ab9842900
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, melatonin, oxidační stres, bolest, stres (fyziologie), volné radikály, oxidative stress, pain, stress (physiology), free radicals, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Melatonin has been shown to play a role in antioxidative defence. We therefore studied its effect on oxidative damage to the rat cerebral cortex evoked by painful stimulation and immobilization-induced stress. Moreover, the effect of melatonin on chronic pain perception was examined. Rats were injected with either a high dose of melatonin (100 mg/kg i.p.) or a vehicle for five days and were subjected to painful stimulation or immobilization stress 30 min after the treatment. To determine the degree of oxidative stress, the levels of free radicals, thiobarbituric acid reactive substances (TBARS) as indicators of lipid peroxidation and glutathione peroxidase (GSHPx) were estimated in somatosensory cortex. Pain perception was measured by the tail-flick and plantar test. Melatonin reduced the level of TBARS previously increased by painful stimulation. Melatonin also exhibited a slight analgesic effect in those animals exposed to painful stimulation but its role in free radical scavenging did not contribute to this effect., I. Pekárková, S. Parara, V. Holeček, P. Stopka, L. Trefil, J. Racek, R. Rokyta., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:6

Harvested from:

CDK

Metadata only:

false