On the cellular mechanisms underlying working memory capacity in humans

Title:

On the cellular mechanisms underlying working memory capacity in humans

Creator:

Spera, E., Migliore, M., Unsworth , N., and Tegolo, D.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:026fe554-7b64-44bf-92b8-9f951ec77e12
uuid:026fe554-7b64-44bf-92b8-9f951ec77e12
doi:10.14311/NNW.2016.26.019

Subject:

working memory capacity, CA1, hippocampus, and data analysis

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

The cellular processes underlying individual differences in the Woring Memory Capacity (WMC) of humans are essentially unknown. Psychological experiments suggest that subjects with lower working memory capacity (LWMC), with respect to subjects with higher capacity (HWMC), take more time to recall items from a list because they search through a larger set of items and are much more susceptible to interference during retrieval. However, a more precise link between psychological experiments and cellular properties is lacking and very difficult to investigate experimentally. In this paper, we investigate the possible underlying mechanisms at the single neuron level by using a computational model of hippocampal CA1 pyramidal neurons, which have been suggested to be deeply involved in the recognition of specific items. The model makes a few experimentally testable predictions on the cellular processes underlying the cumulative latency in delayed free recall experimentally observed in humans under different testing conditions. The results suggest, for the first time, a physiologically plausible explanation for individual performances, and establish a proof of principle for the hypothesis that HWMC individuals use a larger portion of the apical tree with a correlated higher level of synaptic background noise.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Neural network world: international journal on neural and mass-parallel computing and information systems | 2016 Volume:26 | Number:4

Harvested from:

CDK

Metadata only:

false