Lower Omega-3 index is a marker of increased propensity of hypertensive rat heart to malignant arrhythmias

Title:

Lower Omega-3 index is a marker of increased propensity of hypertensive rat heart to malignant arrhythmias

Creator:

Bačová, B., Seč, P., Radošinská, J., Čertík, M., Anna Vachulová, and Narcisa Tribulová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:02c8f77d-a324-4ae1-86bd-efcb161ddf75
uuid:02c8f77d-a324-4ae1-86bd-efcb161ddf75

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, SHR, ω-3 index, ω-3 PUFA intake, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Polyunsaturated omega-3 fatty acids ( ω-3 PUFA) are important components of cell membrane a ffecting its function and their deficiency is deleterious to health. We have previously shown that spontaneously hypertensive rats (SHR) are prone to life- threatening arrhythmias that are reduced by ω-3 PUFA intake. Purpose of this study was to explore plasma and red blood cells (RBC) profile of ω-3 and ω-6 PUFA as well as to determine ω-3 index, a risk factor for sudden cardiac death, in aged SHR and the effect of ω-3 PUFA intake. Male and female 12-month-old SHR and age-matched Wi star rats fed with ω-3 PUFA (200 mg/kg BW/day/2 month) were compared with untreated rats. Composition of ω-3 PUFA: alfa linolenic acid, eicosapentaenoic acid (EPA) and docosahexaen oic acid (DHA) as well as ω-6 PUFA: linoleic acid and arachidonic acid was analyzed by gas chromatography. Results showed sex- and strain-related differences of basal ω-3 and ω-6 PUFA levels in plasma and RBC as well as in response to ω-3 PUFA intake. Comparing to Wistar rats ω-3 index, expressed as a percentage of EPA+DHA of total fatty acids, was lower in SHR and it increased due to consumption of ω-3 PUFA. Findings support our hypothesis that lower ω-3 index may be also a marker of increased propensity of the hypertensive rat heart to malignant arrhythmias., B. Bačová ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false