SARS-CoV-2 viral load assessment in lung transplantation

Title:

SARS-CoV-2 viral load assessment in lung transplantation

Creator:

Novysedlak, Rene, Vachtenheim, Jiri, Striz, Ilja, Viklicky, Ondrej, Lischke, Robert, and Strizova, Zuzana

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:02e802d6-2a41-4fc1-ac0d-d65849b72231
uuid:02e802d6-2a41-4fc1-ac0d-d65849b72231
doi:10.33549/physiolres.934760

Subject:

COVID-19, lung transplantation, organ donor, PCR, and cycle threshold

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

In the era of COVID-19 pandemic, organ transplantation programs were facing serious challenges. The lung transplantation donor pool was extremely limited and SARS-CoV-2 viral load assessment has become a crucial part of selecting an optimal organ donor. Since COVID-19 is a respiratory disease, the viral load is thought to be more important in lung transplantations as compared to other solid organ transplantations. We present two challenging cases of potential lung donors with a questionable COVID-19 status. Based on these cases, we suggest that the cycle threshold (Ct) value should always be requested from the laboratory and the decision whether to proceed with transplantation should be made upon complex evaluation of diverse criteria, including the nasopharyngeal swab and bronchoalveolar lavage PCR results, the Ct value, imaging findings and the medical history. However, as the presence of viral RNA does not ensure infectivity, it is still to be clarified which Ct values are associated with the viral viability. Anti-SARS-CoV-2 IgA antibodies may support the diagnosis and moreover, novel methods, such as quantifying SARS-CoV-2 nucleocapsid antigen in serum may provide important answers in organ transplantations and donor selections.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Coverage:

S253-S258

Source:

Physiological research | 2021 Volume:70 | Number:Supplement 2

Harvested from:

CDK

Metadata only:

false