Aged male and female spontaneously hypertensive rats benefit from n-3 polyunsaturated fatty acids supplementation

Title:

Aged male and female spontaneously hypertensive rats benefit from n-3 polyunsaturated fatty acids supplementation

Creator:

Mitašíková, M., Šmidová, S., Mascaliová, A., Knezl, V., Katarína Dlugošová, Ľudmila Okruhlicová, Weismann, P., and Narcisa Tribulová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:047b7b2a-c804-4e25-8365-17e3f90f94fc
uuid:047b7b2a-c804-4e25-8365-17e3f90f94fc
issn:0862-8408

Subject:

Experimentální medicína, kardiovaskulární fyziologie, fibrilace srdce, myokard, cardiovascular physiology, heart fibrillation, myocardium, spontaneously hypertensive rats (SHR), ventricular fibrilation, connexin-43, myocardial enzymes, DPP4, ultrastructure, 14, and 616-092

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Hypertension-induced myocardial metabolic, structural and electrophysiological remodeling deteriorates with aging and contributes to both heart failure and occurrence of malignant arrhythmias. It has been shown in clinical trials that n-3 polyunsaturated fatty acids (n-3 PUFA) reduce the incidence of cardiovascular diseases and sudden cardiac death. We investigated the cardioprotective effects of n-3 PUFA in aged spontaneously hypertensive rats (SHR) and possible cellular mechanisms involved. Male and female 14-month-old SHR were fed with n-3 PUFA (Vesteralens, Norway, 20 mg/day for two months) and compared with untreated SHR. Results showed that n-3 PUFA supplementation led to 1) significant decline of blood pressure; 2) suppression of inducible ventricular fibrillation (VF) by 57 % (male) and 67 % (female) , although the arrhythmogenic substrates, like fibrosis, hypertrophy and abnormal gap junctions distribution were not eliminated; 3) preservation of the cardiomyocytes and the inte grity of their junctions; 4) enhancement of energetic metabolism enzyme activity; 5) augmentation of capillary density associated with increased alkaline phosphatase and decreased dipeptidyl peptidase-4 (DPP4) activity and 6/ increase in gap junction channel connexin-43 expression. Thus, aged male as well as female SHR benefit from n-3 PUFA supplementation that results in decrease in VF susceptibility, partly due to an improvement of myocardial metabolic state, cardiomyocyte and cell-to-cell junctions integrity and Cx43 up-regulation., M. Mitašíková, S. Šmidová, A. Mascaliová, V. Knezl, K. Dlugošová, Ľ. Okruhlicová, P. Weismann, N. Tribulová., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:Suppl 2

Harvested from:

CDK

Metadata only:

false