Natriuretic peptide resistance of mesenteric arteries in spontaneous hypertensive rat is alleviated by exercise

Title:

Natriuretic peptide resistance of mesenteric arteries in spontaneous hypertensive rat is alleviated by exercise

Creator:

Yu, Jun, Zhang, Bing, Su, Xing-Li, Tie, Ru, Chang, Pan, Zhang, Xue-Ce, Wang, Jian-Bang, Zhao, Ge, Zhu, Miao-Zhang, Zhang, Hai-Feng, and Chen, Bao-Ying

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:057835c5-f3e2-4185-8253-540ef11b41a0
uuid:057835c5-f3e2-4185-8253-540ef11b41a0
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, natriuretické peptidy, hypertenze, natriuretic peptides, hypertension, resistance vessels, cGMP, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Proximal resistance vessels, such as the mesenteric arteries, contribute substantially to the peripheral resistance. The reactivity of resistance vessels to vasoactive substance like natriuretic peptides plays an important role in the regulation of blood pressure. In current study, we investigated the reactivity of mesenteric arteries to atrial natriuretic peptide (ANP), a well known vasodilating factor, in spontaneously hypertensive rats (SHR), as well as the effects of exercise training on it. As a result, ANP-induced vasorelaxation was attenuated in SHR with significantly increased phosphodiesterase type 5 (PDE5), and decreased cGMP/ANP ratio, compared with WKY rats as control. Intriguingly, the decreased reactivity to ANP in SHR was markedly reversed by exercise training. In addition, ANP resistance of in vitro mesenteric arteries was diminished by sildenafil a potent selective inhibitor of PDE5. In conclusion, ANP resistance occurs in resistance vessels of SHR, suggesting predisposition to hypertension, which can be reversed by exercise., Jun Yu, Bing Zhang, Xing-Lu Su, Ru Tie, Pan Chang, Xue-Ce Zhang, Jian-Bang Wang, Ge Zhao, Miao-Zhang Zhu, Hai-Feng Zhang, Bao-Ying Chen., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2016 Volume:65 | Number:2

Harvested from:

CDK

Metadata only:

false