Obesity and infection: receprocal causality

Title:

Obesity and infection: receprocal causality

Creator:

Vojtěch Hainer, Hana Zamrazilová, Marie Kunešová, Běla Bendlová, and Irena Aldhoon Hainerová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:06b5d5ea-e370-4b45-965d-510f0a1c6722
uuid:06b5d5ea-e370-4b45-965d-510f0a1c6722
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, obezita, infekce, kauzalita, adenoviry, obesity, infections, causality, adenoviruses, adenovirus 36, e4orf1 protein, impaired immunity, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Associations between different infectious agents and obesity have been reported in humans for over thirty years. In many cases, as in nosocomial infections, this relationship reflects the greater susceptibility of obese individuals to infection due to impaired immunity. In such cases, the infection is not related to obesity as a causal factor but represents a complication of obesity. In contrast, several infections have been suggested as potential causal factors in human obesity. However, evidence of a causal linkage to human obesity has only been provided for adenovirus 36 (Adv36). This virus activates lipogenic and proinflammatory pathways in adipose tissue, improves insulin sensitivity, lipid profile and hepatic steatosis. The E4orf1 gene of Adv36 exerts insulin senzitizing effects, but is devoid of its pro-inflammatory modalities. The development of a vaccine to prevent Adv36- induced obesity or the use of E4orf1 as a ligand for novel antidiabetic drugs could open new horizons in the prophylaxis and treatment of obesity and diabetes. More experimental and clinical studies are needed to elucidate the mutual relations between infection and obesity, identify additional infectious agents causing human obesity, as well as define the conditions that predispose obese individuals to specific infections., V. Hainer, H. Zamrazilová, M. Kunešová, B. Bendlová, I. Aldhoon-Hainerová., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:Suppl 2

Harvested from:

CDK

Metadata only:

false