Taste Aversion Learning and Aging: A Comparison with the Effect of Dorsal Hippocampal Lesions in Rats

Title:

Taste Aversion Learning and Aging: A Comparison with the Effect of Dorsal Hippocampal Lesions in Rats

Creator:

Moron, I., Ballesteros, M.A., Candido, A., and Gallo, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:0754c442-1fb3-49e1-ac87-94b1d0b2833b
uuid:0754c442-1fb3-49e1-ac87-94b1d0b2833b
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Aging, Conditioned blocking, Hippocampal, Latent inhibition, Taste aversion learning, Rat, 14, and 612

Type:

article, studie, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The relationship between hippocampal function and aging was explored in Wistar rats using taste aversion learning by comparing the performance of adult dorsal hippocampal lesioned and fifteen-month-old intact rats with that of adult intact rats. In experiment 1 the conditioned blocking phenomenon was absent in the hippocampal and the aging rats. Unlike the adult intact rats, the hippocampal and aging rats were not impaired in acquiring a learned aversion to a cider vinegar solution (3 %) presented as a serial compound with a previously conditioned saccharin solution (0.1 %). In experiment 2 both the hippocampal and the aging rats developed reduced aversions to a saline solution (0.5 %) followed by an i.p. injection of lithium chloride (0.15 M; 2 % b.w.) if the taste solution was previously preexposed without consequences. This latent inhibition effect was similar to that seen in intact adult rats. In both experiments, the aging rats exhibited enhanced conventional learned taste aversions. It is concluded that aging is not a unitary process but induces both hippocampal dependent and hippocampal independent complex changes in the functioning of the neural circuits, implementing taste aversion learning., I. Moron, M.A. Ballesteros, A. Candido, M. Gallo., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2002 Volume:51 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false