Respiratory function and dysfunction in Parkinson-type neurodegeneration

Title:

Respiratory function and dysfunction in Parkinson-type neurodegeneration

Creator:

Pokusa, Michal , Hajduchova, Dominika , Buday, Tomas , and Kralova Trancikova, Alzbeta

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:07574eaf-64a6-4f6e-87c2-d2401f432b94
uuid:07574eaf-64a6-4f6e-87c2-d2401f432b94
doi:10.33549/physiolres.934405

Subject:

Parkinson’s disease, respiratory dysfunction, airway defence, animal models, and molecular mechanisms

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

Parkinson's disease (PD) is most commonly manifested by the presence of motor symptoms. However, non-motor symptoms occur several years before the onset of motor symptoms themselves. Hallmarks of dysfunction of the respiratory system are still outside the main focus of interest, whether by clinicians or scientists, despite their indisputable contribution to the morbidity and mortality of patients suffering from PD. In addition, many of the respiratory symptoms are already present in the early stages of the disease and efforts to utilize these parameters in the early diagnosis of PD are now intensifying. Mechanisms that lead to the development and progression of respiratory symptoms are only partially understood. This review focuses mainly on the comparison of respiratory problems observed in clinical studies with available findings obtained from experimental animal models. It also explains pathological changes observed in non-neuronal tissues in subjects with PD.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

S69-S79

Source:

Physiological research | 2020 Volume:69 | Number:Supplement 1

Harvested from:

CDK

Metadata only:

false