The effect of intermittent hypoxic exposure on erythropoietic response and hematological variables in elite athletes

Title:

The effect of intermittent hypoxic exposure on erythropoietic response and hematological variables in elite athletes

Creator:

Kasperska, Anna and Zembron-Lacny, Agnieszka

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:076eeb77-5775-4448-80dd-5f1c7b0b2c47
uuid:076eeb77-5775-4448-80dd-5f1c7b0b2c47
doi:10.33549/physiolres.934316

Subject:

erythropoietin, hypoxia, nitric oxide, reticulocytes, and athletes

Type:

model:article and TEXT

Format:

počítač and online zdroj

Description:

This study aimed to evaluate the changes in the erythropoietin level and hematological variables in wrestlers after intermittent hypoxic exposure (IHE). Twelve wrestlers were assigned into two groups: hypoxia (sports training combined with IHE, n=6) and control (sports training, n=6). An IHE was performed for 10 days, with one day off after 6 days, once a day for about an hour. The concentrations of hydrogen peroxide (H2O2), nitric oxide (NO), vascular endothelial growth factor (VEGF) and erythropoietin (EPO), as well as total creatine kinase activity (CK) were measured. Also, the hematological markers (Hb -hemoglobin, Ht - hematocrit, RBC - red blood cell, WBC - white blood cell, Ret - reticulocytes) were analyzed. The 6-day IHE caused an increase in the levels of H2O2, NO and VEGF. Similarly, the EPO level and WBC count reached the highest value after 6 days of IHE. The total Ret number increase constantly during 10 days of IHE. The hypoxia group showed a higher CK activity compared to the control. In conclusion, 10-day IHE in combination with wrestling training elevates levels of H2O2, NO and VEGF, and improves the oxygen transport capacity by the release of EPO and Ret in circulation.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

283-290

Source:

Physiological research | 2020 Volume:69 | Number:2

Harvested from:

CDK

Metadata only:

false