Alterations in endothelin receptors following hemorrhage and resuscitation by centhaquin

Title:

Alterations in endothelin receptors following hemorrhage and resuscitation by centhaquin

Creator:

Briyal, S., Gandhakwala, R., Gulati, A., Lavhale, M. S., and Khan, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:081d0f07-4a4f-4e3b-ad9d-d0658332b2e4
uuid:081d0f07-4a4f-4e3b-ad9d-d0658332b2e4
issn:0862-8408

Subject:

fyziologie člověka, human physiology, Hemorrhagic shock, Centhaquin, Resuscitation, Endothelin, Cytokines, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

Endothelin-1 (ET-1) acts on ETA and ETB receptors and has been implicated in hemorrhagic shock (shock). We determined effect of shock and resuscitation by hypertonic saline (saline) or centhaquin on ETA and ETB receptor expression. Rats were anesthetized, a pressure catheter was placed in the left femoral artery; blood was withdrawn from the right femoral artery to bring mean arterial pressure (MAP) to 35 mm Hg for 30 min, resuscitation was performed and 90 min later sacrificed to collect samples for biochemical estimations. Resuscitation with centhaquin decreased blood lactate and increased MAP. Protein levels of ETA or ETB receptor were unaltered in the brain, heart, lung and liver following shock or resuscitation. In the abdominal aorta, shock produced an increase (140 %) in ETA expression which was attenuated by saline and centhaquin; ETB expression was unaltered following shock but was increased (79 %) by centhaquin. In renal medulla, ETA expression was unaltered following shock, but was decreased (-61 %) by centhaquin; shock produced a decrease (-34 %) in ETB expression which was completely attenuated by centhaquin and not saline. Shock induced changes in ETA and ETB receptors in the aorta and renal medulla are reversed by centhaquin and may be contributing to its efficacy., S. Briyal, R. Gandhakwala, M. Khan, M. S. Lavhale, A. Gulati., and Seznam literatury

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false