Bone microstructure of mice after prolonged taurine treatment

Title:

Bone microstructure of mice after prolonged taurine treatment

Creator:

Martiniakova, M. , Sarocka, A., Babosova, R. , Galbavy, D. , Kapusta, E., Goc, Z., Formicki, G. , and Omelka, R.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:093e73bc-295a-4684-9c59-d8aaa9721466
uuid:093e73bc-295a-4684-9c59-d8aaa9721466
doi:10.33549/physiolres.934139

Subject:

taurine, bone, mouse, and microstructure

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Taurine, a sulphur - containing amino acid, has been termed a functional nutrient. Its synthetic form is a common ingredient in supplements and energy drinks. There is no information concerning taurine impact on bone microstructure after prolonged supplemental use. Also, differences in bone parameters of mice following taurine exposure are unknown. In this study, a detailed microstructure of compact and trabecular bone tissues of mice subchronically exposed to taurine was determined. Animals (n=12) were segregated into three groups: E1 group – mice received 20 mg/kg b.w. of taurine per day during 8 weeks; E2 group – mice were fed by taurine at a dose of 40 mg/kg b.w. for 8 weeks and a control (C) group. Decreased density of secondary osteons, increased sizes of primary osteon's vascular canals (P<0.05) were observed in taurine – treated animals. Cortical bone thickness, trabecular thickness were decreased (P<0.05) in E1 group, and relative volume of trabecular bone was lower (P<0.05) in E2 group as compared to C group. According to our results, prolonged taurine exposure at the doses used in this study can negatively affect both compact and trabecular bone tissues microstructure.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

519-523

Source:

Physiological research | 2019 Volume:68 | Number:3

Harvested from:

CDK

Metadata only:

false