Inhibition of palmityl carnitine oxidation in rat liver mitochondria by tert-butyl hydroperoxide

Title:

Inhibition of palmityl carnitine oxidation in rat liver mitochondria by tert-butyl hydroperoxide

Creator:

Zuzana Červinková, Hana Rauchová, Pavla Křiváková, and Zdeněk Drahota

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:09c82d91-d313-4fd6-a9e1-41633babc410
uuid:09c82d91-d313-4fd6-a9e1-41633babc410
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, mitochondrie, játra, physiology, mitochondrias, liver, palmityl carnitine oxidation, tert-butyl hydroperoxide, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Mitochondria as an energy generating cell device are very sensitive to oxidative damage. Our previous findings obtained in hepatocytes demonstrated that Complex I of the respiratory chain is more sensitive to oxidative damage than other respiratory chain complexes. We present additional data on isolated mitochondria showing that palmityl carnitine oxidation is strongly depressed at a low (200 μM) tert-butyl hydroperoxide (tBHP) concentration, while oxidation of the flavoprotein-dependent substrate - succinate is not affected and neither is ATP synthesis inhibited by tBHP. In the presence of tBHP, the respiratory control index for palmityl carnitine oxidation is strongly depressed, but when succinate is oxidized the respiratory control index remains unaffected. Our findings thus indicate that flavoprotein-dependent substrates could be an important nutritional factor for the regeneration process in the necrotic liver damaged by oxidative stress., Z. Červinková, H. Rauchová, P. Křiváková, Z. Drahota., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:1

Harvested from:

CDK

Metadata only:

false