Variability of mitochondrial respiration in relation to sepsis-induced multiple organ dysfunction

Title:

Variability of mitochondrial respiration in relation to sepsis-induced multiple organ dysfunction

Creator:

Kohoutová, M., Dejmek, J., Tůma, Z., and Kuncová, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:09da74eb-54c7-4ae8-ae97-90b7aec2f12f
uuid:09da74eb-54c7-4ae8-ae97-90b7aec2f12f

Subject:

sepsis, mitochondria, oxygen consumption, multiple organ dysfunction, and animal models

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Ample experimental evidence suggests that sepsis could interfere with any mitochondrial function; however, the true role of mitochondrial dysfunction in the pathogenesis of sepsis-induced multiple organ dysfunction is still a matter of controversy. This review is primarily focused on mitochondrial oxygen consumption in various animal models of sepsis in relation to human disease and potential sources of variability in experimental results documenting decrease, increase or no change in mitochondrial respiration in various organs and species. To date, at least three possible explanations of sepsis-associated dysfunction of the mitochondrial respiratory system and consequently impaired energy production have been suggested: 1. Mitochondrial dysfunction is secondary to tissue hypoxia. 2. Mitochondria are challenged by various toxins or mediators of inflammation that impair oxygen utilization (cytopathic hypoxia). 3. Compromised mitochondrial respiration could be an active measure of survival strategy resembling stunning or hibernation. To reveal the true role of mitochondria in sepsis, sources of variability of experimental results based on animal species, models of sepsis, organs studied, or analytical approaches should be identified and minimized by the use of appropriate experimental models resembling human sepsis, wider use of larger animal species in preclinical studies, more detailed mapping of interspecies differences and organ-specific features of oxygen utilization in addition to use of complex and standardized protocols evaluating mitochondrial respiration.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:Suppl 4

Harvested from:

CDK

Metadata only:

false