Influence of dynorphin A (1-13) and dynorphin A (1-10) amide on stress-induced analgesia

Title:

Influence of dynorphin A (1-13) and dynorphin A (1-10) amide on stress-induced analgesia

Creator:

Starec, M., Rosina, J., Málek, J., and Kršiak, M.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:0a95c4cf-576e-43c0-b76f-2b32a5e103cf
uuid:0a95c4cf-576e-43c0-b76f-2b32a5e103cf

Subject:

dynorphin, stress, analgesia, kappa opioids, and mice

Type:

article, model:article, and TEXT

Description:

Dynorphin A (1-13) and its analog dynorphin A (1-10) amide were applied intracerebroventricularly in male ICR mice. Both dynorphins did not reveal any analgesic activity in tail-flick test under normal (non-stressed) conditions. However, in combination with stress (forced swimming or whole body vibration) both dynorphins prolonged tail- flick latencies when compared with stressed saline controls. Naloxone inhibited the effect of dynorphins in forced swimming test. Neither dynorphin A (1-13) nor dynorphin A (1-10) amide increased tail-flick latencies when combined with weak immobilization stress. Our results suggest that the analgesic effects of dynorphins are potentiated by strong stressors.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1996 Volume:45 | Number:6

Harvested from:

CDK

Metadata only:

false