Ontogenesis of melatonin receptors in anterior pituitary and pars tuberalis of golden hamsters

Title:

Ontogenesis of melatonin receptors in anterior pituitary and pars tuberalis of golden hamsters

Creator:

Vaněček, J. and Kosař, E.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:0ba83891-13d8-41e1-96a8-fd8c5629f251
uuid:0ba83891-13d8-41e1-96a8-fd8c5629f251

Subject:

melatonin receptor, anterior pituitary, pars tuberalis, ontogenesis, and golden hamster

Type:

article, model:article, and TEXT

Description:

The ontogenesis of melatonin receptors in the anterior pituitary and pars tuberalis of the Golden hamster was studied using [125l]iodomelatonin as a ligand. The affinity of the binding site to the ligand (K<j) was in the range 21 to 54 pM and it did not change significantly during development. The concentration of the [125lliodomelatonin binding sites in the anterior pituitary was highest in one-day-old hamsters (Bmax=14 fmol/mg protein) and thereafter gradually decreased. In adults it reached to about 6 % of the neonatal values. In contrast, the concentration of the binding sites in pars tuberalis did not change significantly during ontogenesis and it was in the range of 3 to 5 fmol/mg protein.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1994 Volume:43 | Number:6

Harvested from:

CDK

Metadata only:

false