The relationship between iodine intake and serum thyroglobulin in the general population

Title:

The relationship between iodine intake and serum thyroglobulin in the general population

Creator:

Radovan Bílek, Jarmila Čeřovská, and Václav Zamrazil

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:0cd46830-c4f2-4e31-9d77-9da8425e24d8
uuid:0cd46830-c4f2-4e31-9d77-9da8425e24d8
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, jod, toleranční meze, iodine, tolerance limits, thyroglobulin, population studies, normal individuals, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

The relationship is shown between a concentration of urinary iodine and serum thyroglobulin in population studies carried out on a general population that was randomly selected from the registry of the General Health Insurance Company (individuals aged 6-98 years, 1751 males, 2420 females). The individuals were divided into subgroups with a urinary iodine concentration of <50, 50-99, 100-199, 200-299 and ≥300 μg/l. The mean and median of thyroglobulin were calculated in these subgroups. Tg concentrations were dependent on gender (males<females), age (thyroglobulin increased with age) and statistically significant negative relationship was observed between thyroglobulin and urinary iodine in individuals with urinary iodine <300 μg/l and the age under 65 years. Upper nonparametric tolerance limits of thyroglobulin in relation to iodine intake were calculated in subgroup of normal individuals (n=1858, thyroglobulin, urinary iodine, thyrotropin and free thyroxine were within the normal reference range). Upper limits were dependent on gender and age. The total value of upper limits is 44 μg/l; for individuals aged 6-17 years it is 39.1 μg/l; 18-65 years = 51.4 μg/l and 66-98 years = 60.6 μg/l. In general, thyroglobulin serum concentrations higher than 40 μg/l should be an indicator for determining urinary iodine., R. Bílek, J. Čeřovská, V. Zamrazil., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:3

Harvested from:

CDK

Metadata only:

false