Pressure overload selectively increases n-3 PUFA in myocardial phospholipids during early postnatal period

Title:

Pressure overload selectively increases n-3 PUFA in myocardial phospholipids during early postnatal period

Creator:

Novák, F., František Kolář, Voců, Š., Marek Vecka, and Olga Nováková

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:0d5547cb-879e-4e7d-b246-b174bd7534e3
uuid:0d5547cb-879e-4e7d-b246-b174bd7534e3

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, phospholipids, n-3 PUFA, myocardium, postnatal development, pressure overload, rat, 14, and 612

Type:

article, články, model:article, and TEXT

Description:

Increasing hemodynamic load during early postnatal development leads to rapid growth of the left ventricular (LV) myocardium, which is associated with membrane phospholipid (PL) remodeling characterized by n-3 polyunsaturated fatty acids (PUFA) accumulation. The aim of this study was to examine the influence of additional workload imposed early after birth when ventricular myocytes are still able to proliferate. Male Wistar rats were subjected to abdominal aortic constriction (AC) at postnatal day 2. Concentrations of PL and their fatty acid (FA) profiles in the LV were analyzed in AC, sham-operated (SO) and intact animals on postnatal days 2 (intact only), 5 and 10. AC resulted in LV enlargement by 22 % and 67 % at days 5 and 10, respectively, compared with age-matched SO littermates. Concentrations of phosphatidylcholine, cardiolipin, phosphatidylinositol, phosphatidylethanolamine, phosphatidylserine and sphingomyelin decreased in AC myocardium, albeit with different time course and extent. The main effect of AC on FA remodeling consisted in the accumulation of n-3 PUFA in PL. The most striking effect of AC on FA composition was observed in phosphatidylinositol and cardiolipin. We conclude that excess workload imposed by AC inhibited the normal postnatal increase of PL concentration while further potentiating the accumulation of n-3 PUFA as an adaptive response of the developing myocardium to accelerated growth., F. Novák, ... [et al.]., and Obsahuje seznam literatury

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2012 Volume:61 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false