Differences in serum steroid hormones concentrations in spontaneously hypertensive rats (SHR) - an animal model of attention-deficit/hyperactivity disorder (ADHD)

Title:

Differences in serum steroid hormones concentrations in spontaneously hypertensive rats (SHR) - an animal model of attention-deficit/hyperactivity disorder (ADHD)

Creator:

Kozłowska, A., Wojtacha, P., Równiak, M., Kolenkiewicz, M. , and Tsai , M.-L.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:0fd07600-63d5-4cc3-869d-c4fbcb3af877
uuid:0fd07600-63d5-4cc3-869d-c4fbcb3af877
doi:10.33549/physiolres.933907

Subject:

hormones, ADHD, and spontaneously hypertensive rats

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Spontaneously hypertensive rats are the most common animal model used to study attention deficit hyperactivity disorder (ADHD). The present study investigated the levels of steroid hormones in the bloodstream of hypertensive rats and its normotensive control strain, Wistar-Kyoto rats, to check if there are any hormonal differences between both strains at the onset of ADHD. Plasma samples were collected from young (5-weekold) and mature (10-week-old) male hypertensive and normotensive rats to determine the serum level of testosterone, 17β-estradiol, free estriol, progesterone, corticosterone and cortisol using ELISA kits. The results showed statistically significant increases in serum levels of testosterone and free estriol in 10-week-old hypertensive and normotensive rats when compared to 5-week-old animals. Moreover, the concentrations of progesterone, corticosterone and cortisol were significantly elevated in 10-week-old hypertensive rats when compared to 5-week-old animals of both strains as well as 10-week-old normotensive rats. Hormonal differences observed between 10-week-old hypertensive and normotensive rats were also accompanied by differences in the volumes of lateral ventricles as well as the third ventricle and cerebral aqueduct. In conclusion, elevated contents of progesterone, corticosterone and cortisol in hypertensive rats may be associated not only with ADHD but also with developing hypertension. This question needs further study.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2019 Volume:68 | Number:1

Harvested from:

CDK

Metadata only:

false