Budesonide added to modified porcine surfactant curosurf may additionally improve the lung functions in meconium aspiration syndrome

Title:

Budesonide added to modified porcine surfactant curosurf may additionally improve the lung functions in meconium aspiration syndrome

Creator:

Mikolka, P., Daniela Mokrá, Kopincová, J., Tomčíková-Mikušiaková, L., and Andrea Čalkovská

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:10d54abf-e20f-4dfd-bb22-e26bb9411cee
uuid:10d54abf-e20f-4dfd-bb22-e26bb9411cee

Subject:

Fyziologie člověka a srovnávací fyziologie, budesonid, záněty, budesonide, inflammations, curosurf, exogenous surfactant, meconium aspiration, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Severe meconium aspiration sy ndrome (MAS) in newborns is often treated by exogenous surfac tant. Because its efficacy is reduced by meconium-induced inflammation, glucocorticoid budesonide was added into surfac tant preparation Curosurf to enhance efficacy of the surfactant therapy in experimental model of MAS. Oxygen-ventilated rabbits were intratracheally given meconium (25 mg/ml, 4 ml/kg) to induce respiratory failure. Thirty minutes later, animals were treated by intratracheal budesonide (0.25 mg/kg) ; or surfactant lung lavage (10 ml/kg, 5 mg phospholipids/ml) repeated twice, followed by undiluted Curosurf (100 mg phospholipids/kg) ; or by the above mentioned surfactant treatment with the last surfactant dose fortified with budesonide (0.25 mg/kg) ; or were untreated. Animals were ventilated for additional 5 hours and respiratory parameters were measured regularly. After sacrificing animals, wet-dry lung weight ratio was evaluated and plasma levels of interleukins (IL)-1beta, -6, -8, and TNF-alpha were measured by ELISA method. Efficacy of the given therapies to enhance lung functions and to diminish lung edema formation and in flammation increased from budesonide-only and surf actant-only therapy to surfactant+budesonide therapy. Combined therapy improved gas exchange from 30 min of administration, and showed a longer- lasting effect than surfactant-only therapy. In conclusions, budesonide additionally improv ed the effects of exogenous surfactant in experimental MAS., P. Mikolka ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false