Concentrations of Free Mg2+, pH and 31P MR Metabolite Ratios in Calf Muscles of Healthy Controls and Patients with Primary Juvenile Hypertension

Title:

Concentrations of Free Mg2+, pH and 31P MR Metabolite Ratios in Calf Muscles of Healthy Controls and Patients with Primary Juvenile Hypertension

Creator:

Hájek, Matěj, Palyzová, D., Kořínek, M., and Kurková, D.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:117814f6-3758-49c8-8d87-8fdd2c742e83
uuid:117814f6-3758-49c8-8d87-8fdd2c742e83
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, Concentration Mg2+, pH, Muscles, 31P MR spectroscopy, Juvenile hypertension, 14, and 612

Type:

article, studie, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

31P MR spectroscopy was used to measure the signal intensity ratios of high-energy metabolites for the calculation of free cytosolic magnesium concentration [fMg2+] and pH in the calf muscles of patients with primary juvenile hypertension and of healthy controls. Surface coil and spectroscopic imaging techniques were used. In patients with hypertension, the concentrations of [fMg2+] was 788±33 mmol/l and intracellular pH was 7.05±0.02; these values were not significantly different from the results obtained in healthy controls ([fMg2+], 776±21 mmol/l and pH, 7.06±0.01). Biochemical assays of magnesium in the serum (S-Mg) and in urine (DU-Mg) confirmed this finding. Significant differences in the relative signal intensities of high-energy phosphates between patients with primary juvenile hypertension and healthy controls were observed: a) signal intensity ratios of PCr/Pi, PCr/PbATP, PDE/PbATP were increased, and b) Pi/PDe, Pi/PATP were decreased. The results were the same irrespective of whether the surface coil method or 31P spectroscopic imaging were employed., M. Hájek, D. Palyzová, M. Kořínek, D. Kurková., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2002 Volume:51 | Number:2

Harvested from:

CDK

Metadata only:

false