Resveratrol alleviates ethanol-induced hormonal and metabolic disturbances in the rat

Title:

Resveratrol alleviates ethanol-induced hormonal and metabolic disturbances in the rat

Creator:

Szkudelska, K., Deniziak, M., Roś, P., Gwóźdź, K., and Szkudelski, T.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:11db872e-f268-4494-96b7-3c58db9b7bcb
uuid:11db872e-f268-4494-96b7-3c58db9b7bcb
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, ethanol, hormony, metabolismus, hormones, metabolism, resveratrol, rats, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Resveratrol is a polyphenol found in different plant species and having numerous health-promoting properties in animals and humans. However, its protective action against deleterious effects of ethanol is poo rly elucidated. In the present study, the influence of resveratrol (10 mg/kg/day) on some hormones and metabolic parameters was determined in rats ingesting 10 % ethanol solution for two weeks. Blood levels of insulin, glucagon and adiponectin were affecte d by ethanol, however, resveratrol partially ameliorated these changes. Moreover, in ethanol drinking rats, liver lipid accumulation was increased, whereas resveratrol was capable of reducing liver lipid content, probably due to decrease in fatty acid synt hesis. Resveratrol decreased also blood levels of triglycerides and free fatty acids and reduced γ-glutamyl transferase activity in animals ingesting ethanol. These results show that resveratrol, already at low dose, alleviates hormonal and metabolic changes induced by ethanol in the rat and may be useful in preventing and treating some consequences o f alcohol consumption., K. Szkudelska, M. Deniziak, P. Roś, K. Gwóźdź, T. Szkudelski., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:1

Harvested from:

CDK

Metadata only:

false