Use of electrogastrography in preclinical studies of cholinergic and anticholinergic agents in experimental pigs

Title:

Use of electrogastrography in preclinical studies of cholinergic and anticholinergic agents in experimental pigs

Creator:

Jaroslav Květina, Ilja Tachecí, Pavlík, M., Marcela Kopáčová, Stanislav Rejchrt, Tomáš Douda, Martin Kuneš, and Jan Bureš

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:12034553-bc9e-4030-8743-4d6e49106a44
uuid:12034553-bc9e-4030-8743-4d6e49106a44
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, electrogastrography, experimental pigs, atropine, neostigmine, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Electrogastrography (EGG) is a non-invasive method for the assessment of gastric myoelectrical activity. Porcine EGG is comparable with human one. The purpose of this study was to evaluate the effect of atropine and neostigmine on the EGG in experimental pigs. Adult female pigs were administrated atropine (1.5 mg i.m., n=6) and neostigmine (0.5 mg i.m., n=6) after the baseline EGG, followed by a 90-min trial recording (MMS, Enschede, the Netherlands). Running spectral analysis was used for the evaluation. The results were expressed as dominant frequency of slow waves and EGG power (areas of amplitudes). Neostigmine increased continuously the dominant frequency and decreased significantly the EGG power. Atropine did not change the dominant frequency significantly. However, atropine increased significantly the EGG power (areas of amplitudes) from basal values to the maximum at the 10-20-min interval. After that period, the areas of amplitudes decreased significantly to the lowest values at the 60-90-min interval. In conclusion, cholinergic and anticholinergic agents affect differently EGG in experimental pigs., J. Květina, I. Tachecí, M. Pavlík, M. Kopáčová, S. Rejchrt, T. Douda, M. Kuneš, J. Bureš., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2015 Volume:64 | Number:Suppl 5

Harvested from:

CDK

Metadata only:

false