Heart failure and angiotensin converting enzyme inhibition: problems and perspectives

Title:

Heart failure and angiotensin converting enzyme inhibition: problems and perspectives

Creator:

Fedor Šimko and Šimko, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:12cde4cc-98a6-42b4-81db-56aa51d09af2
uuid:12cde4cc-98a6-42b4-81db-56aa51d09af2
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, srdeční selhání, heart failure, ACE inhibitors, Angiotensin II receptor antagonists, beta-blockers, local angiotensin II, chymase, neurohumoral activation, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Heart failure has become the most widely studied syndrome in cardiology over the recent years. Despite the encouraging achievements by angiotensin converting enzyme (ACE) inhibitors, the mortality of patients with chronic heart failure remains high. There are several factors which can potentially be responsible for the fact that about 80% of patients with a failing heart defy protection by ACE inhibitors: different activation of tissue and systemic renin-angiotensin system (RAS) in a particular heart disease and the distinct ability of various ACE inhibitors to block cardiac ACE, alternative pathways for angiotensin II formation (chymase), genetic polymorphism of the RAS system and the complexity of neuroendocrine activation. Moreover, chronic heart failure can provoke disturbances in the reactivity of peripheral vessels and metabolism of striated muscles. These factors may then potentiate the vicious circle of heart failure. New therapeutic approaches, which could further reduce the mortality in patients with heart failure involve angiotensin II type 1 receptor antagonists, beta-blockers, aldosterone antagonists and blockers of the endothelin receptor. A number of questions associated with functions of the RAS still remain open and their solution could be of substantial benefit for patients with a failing heart., F. Šimko, J. Šimko., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1999 Volume:48 | Number:1

Harvested from:

CDK

Metadata only:

false